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344930 Furin Inhibitor I - Calbiochem

Furin Inhibitor I, is a peptidyl chloromethylketone that binds to the catalytic site of furin and blocks its activity.

Furin Inhibitor I - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Decanoyl-RVKR-CMK

Primary Target: viral glycoproteins
344930
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₃₄H₆₆ClN₁₁O₅

Products

Catalogue NumberPackaging Qty/Pack
344930-150MG Plastic ampoule 150 mg
344930-1MG Plastic ampoule 1 mg
Description
OverviewA peptidyl chloromethylketone that binds to the catalytic site of furin and blocks its activity. Hence, it can be used as a high specificity cleavage inhibitor of viral glycoproteins and blocker of viral replication. Reported to block the shedding of MT5-MMP by furin and prevent the activation of MT5-MMP. Also shown to reduce the pro-peptide cleavage of BACE (β-site APP-cleaving enzyme).
Catalogue Number344930
Brand Family Calbiochem®
SynonymsDecanoyl-RVKR-CMK
References
ReferencesSugrue, R.J., et al. 2001. J. Gen. Virol. 82, 1375.
Wang, X., and Pei, D. 2001. J. Biol. Chem. 276, 35953.
Capell, A., et al. 2000. J. Biol. Chem. 275, 30849.
Denault, J.B., et al. 1995. FEBS Lett. 362, 276.
Denault, J.B., et al. 1995. J. Cardiovasc. Pharmacol. 26, S47.
Garten, W., et al. 1994. Biochimie 76, 217.
Hallenberger, S., et al. 1992. Nature 360, 358.
Stieneke-Gröber, A., et al. 1992. EMBO J. 11, 2407.
Product Information
FormOff-white solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₃₄H₆₆ClN₁₁O₅
Chemical formulaC₃₄H₆₆ClN₁₁O₅
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetviral glycoproteins
Purity≥90% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceDecanoyl-Arg-Val-Lys-Arg-CMK
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
344930-150MG 04055977194388
344930-1MG 04055977194371

Documentation

Furin Inhibitor I - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Furin Inhibitor I - Calbiochem Certificates of Analysis

TitleLot Number
344930

References

Reference overview
Sugrue, R.J., et al. 2001. J. Gen. Virol. 82, 1375.
Wang, X., and Pei, D. 2001. J. Biol. Chem. 276, 35953.
Capell, A., et al. 2000. J. Biol. Chem. 275, 30849.
Denault, J.B., et al. 1995. FEBS Lett. 362, 276.
Denault, J.B., et al. 1995. J. Cardiovasc. Pharmacol. 26, S47.
Garten, W., et al. 1994. Biochimie 76, 217.
Hallenberger, S., et al. 1992. Nature 360, 358.
Stieneke-Gröber, A., et al. 1992. EMBO J. 11, 2407.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-June-2008 RFH
SynonymsDecanoyl-RVKR-CMK
DescriptionA peptidyl chloromethylketone that binds irreversibly to the catalytic site of furin and blocks its activity. Hence, it can be used as a high specificity cleavage inhibitor of viral glycoproteins and blocker viral replication. Reported to block the shedding of MT5-MMP by furin and prevent the activation of MT5-MMP. Completely inhibits the cleavage of Boc-RVRR-AMC (50 µM) by purified furin or PACE4. Also inhibits the activity of endothelin converting enzyme and reduces the pro-peptide cleavage of BACE (β-site APP-cleaving enzyme).
FormOff-white solid
FormulationSupplied as a trifluoroacetate salt.
Chemical formulaC₃₄H₆₆ClN₁₁O₅
Peptide SequenceDecanoyl-Arg-Val-Lys-Arg-CMK
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityDMSO or Methanol (1 mg/ml)
Storage Protect from moisture
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesSugrue, R.J., et al. 2001. J. Gen. Virol. 82, 1375.
Wang, X., and Pei, D. 2001. J. Biol. Chem. 276, 35953.
Capell, A., et al. 2000. J. Biol. Chem. 275, 30849.
Denault, J.B., et al. 1995. FEBS Lett. 362, 276.
Denault, J.B., et al. 1995. J. Cardiovasc. Pharmacol. 26, S47.
Garten, W., et al. 1994. Biochimie 76, 217.
Hallenberger, S., et al. 1992. Nature 360, 358.
Stieneke-Gröber, A., et al. 1992. EMBO J. 11, 2407.