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344149 FPRL1 Agonist II, C43 - Calbiochem

FPRL1 Agonist II, C43 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-(4-chlorophenyl)-3-(5-isopropyl-1-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)urea, Formyl Peptide Receptor-Like 1 Agonist II, FPR2 Agonist II, ALX Agonist II

344149
  
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Overview

Replacement Information
Description
Overview

This product has been discontinued.



An orally available, stable, pyrazolone derivative that acts as a potent prototypic agonist of human formyl-peptide-like 1 receptor (hFPRL1; FPR2) (EC50 = 44 nM). Also shown to block polymorphonuclear neutrophil (PMN) migration in a dose-dependent manner, irrespective of the type of stimulant applied. Reported to act by activating extracellular loop I, while the downstream signaling effects are attributed to its loop II region. Does not affect several other protein targets studied, such as p38a, CXCR2, histamine receptor, and TRPV1 (~10 mM). Exhibit suitable pharmacokinetic properties, such as low clearance (126 ml/h/kg) and a half-life of ~2.78 hours. Shown to significantly reduce edema in mouse ear (~50 mg/kg) following oral administration.
Catalogue Number344149
Brand Family Calbiochem®
Synonyms1-(4-chlorophenyl)-3-(5-isopropyl-1-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)urea, Formyl Peptide Receptor-Like 1 Agonist II, FPR2 Agonist II, ALX Agonist II
References
ReferencesBena, S., et al. 2012, J Biol Chem 287, 24690.
Burli, R. W, et al. 2006, Bioorg Med Chem Lett. 16, 3713.
Product Information
FormLight brown powder
Hill FormulaC₂₀H₂₁ClN₄O₂
Chemical formulaC₂₀H₂₁ClN₄O₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥93% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
344149 0

Documentation

FPRL1 Agonist II, C43 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Bena, S., et al. 2012, J Biol Chem 287, 24690.
Burli, R. W, et al. 2006, Bioorg Med Chem Lett. 16, 3713.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-April-2013 JSW
Synonyms1-(4-chlorophenyl)-3-(5-isopropyl-1-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)urea, Formyl Peptide Receptor-Like 1 Agonist II, FPR2 Agonist II, ALX Agonist II
DescriptionAn orally available, stable, pyrazolone derivative that acts as a potent prototypic agonist of human formyl-peptide-like 1 receptor (hFPRL1; FPR2) (EC50 = 44 nM). Also shown to block polymorphonuclear neutrophil (PMN) migration in a dose-dependent manner, irrespective of the type of stimulant applied. Reported to act by activating extracellular loop I, while the downstream signaling effects are attributed to its loop II region. Does not affect several other protein targets studied, such as p38a, CXCR2, histamine receptor, and TRPV1 (~10 mM). Exhibit suitable pharmacokinetic properties, such as low clearance (126 ml/h/kg) and a half-life of ~2.78 hours. Shown to significantly reduce edema in mouse ear (~50 mg/kg) following oral administration.
FormLight brown powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₀H₂₁ClN₄O₂
Structure formulaStructure formula
Purity≥93% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBena, S., et al. 2012, J Biol Chem 287, 24690.
Burli, R. W, et al. 2006, Bioorg Med Chem Lett. 16, 3713.