Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

324680 Ellipticine, 9-Hydroxy-, Hydrochloride

Ellipticine, 9-Hydroxy-, Hydrochloride MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 9-HE, HCl

324680
  
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
OverviewA cell-permeable antitumor alkaloid that acts as a potent inhibitor of topoisomerase II (IC50 = 3.3 µM). Restores functional wild-type p53 activity via inhibition of mutant p53 protein phosphorylation. Suppresses Cdk2 activity in a concentration-dependent manner. Also reported to inhibit telomerase activity in cultured pancreatic cells, possibly through inhibition of protein kinases. Binds to the aryl hydrocarbon receptor (AhR) in rat lung cytosol and inhibits aryl hydrocarbon hydroxylase (AHH) activity in rat hepatic microsomes.
Catalogue Number324680
Brand Family Calbiochem®
Synonyms9-HE, HCl
References
ReferencesMizumoto, K., et al. 2000. Cancer Lett. 149, 85. Perry, P.J., et al. 1999. Anticancer Drug Des. 14, 373. Sugikawa, E., et al. 1999. Anticancer Res. 19, 3099. Sato, N., et al. 1998. FEBS Lett. 441, 318. Ohashi, M., et al. 1995. Jpn. J. Cancer Res. 86, 819. Renault, G., et al. 1987. Toxicol. Appl. Pharmacol. 89, 281.
Product Information
CAS number52238-35-4
FormBrown solid
Hill FormulaC₁₇H₁₄N₂O · HCl
Chemical formulaC₁₇H₁₄N₂O · HCl
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary Targettopoisomerase 2
Primary Target IC<sub>50</sub>3.3 µM
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 23/24/25-40

Toxic by inhalation, in contact with skin and if swallowed.
Limited evidence of a carcinogenic effect.
S PhraseS: 36/37/39-45

Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution in water, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 6 months at -20°C. PBS stock solutions are unstable; reconstitute just prior to use.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
324680 0

Documentation

Ellipticine, 9-Hydroxy-, Hydrochloride Certificates of Analysis

TitleLot Number
324680

References

Reference overview
Mizumoto, K., et al. 2000. Cancer Lett. 149, 85. Perry, P.J., et al. 1999. Anticancer Drug Des. 14, 373. Sugikawa, E., et al. 1999. Anticancer Res. 19, 3099. Sato, N., et al. 1998. FEBS Lett. 441, 318. Ohashi, M., et al. 1995. Jpn. J. Cancer Res. 86, 819. Renault, G., et al. 1987. Toxicol. Appl. Pharmacol. 89, 281.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-April-2008 RFH
Synonyms9-HE, HCl
DescriptionA cell-permeable, antitumor alkaloid that acts as a potent inhibitor of topoisomerase II(IC50 = 3.3 µM). Restores functional wild-type p53 activity via inhibition of mutant p53 protein phosphorylation. Shown to induce apoptosis in Saos-2 osteosarcoma cells by arresting cells at G1 stage of the cell cycle. Suppresses Cdk2 activity in a concentration-dependent manner. Also reported to inhibit telomerase activity in cultured pancreatic cancer cells, in a time- and concentration-dependent manner, possibly through inhibition of protein kinases. Binds to the aryl hydrocarbon receptor (AhR) in rat lung cytosol and inhibits aryl hydrocarbon hydroxylase (AHH) activity in rat hepatic microsomes.
FormBrown solid
Intert gas (Yes/No) Packaged under inert gas
CAS number52238-35-4
Chemical formulaC₁₇H₁₄N₂O · HCl
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityPBS or H₂O
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution in water, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 6 months at -20°C. PBS stock solutions are unstable; reconstitute just prior to use.
Toxicity Toxic & Carcinogenic / Teratogenic
ReferencesMizumoto, K., et al. 2000. Cancer Lett. 149, 85. Perry, P.J., et al. 1999. Anticancer Drug Des. 14, 373. Sugikawa, E., et al. 1999. Anticancer Res. 19, 3099. Sato, N., et al. 1998. FEBS Lett. 441, 318. Ohashi, M., et al. 1995. Jpn. J. Cancer Res. 86, 819. Renault, G., et al. 1987. Toxicol. Appl. Pharmacol. 89, 281.