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532383 Donecopride Fumarate - Calbiochem

A cell permeable, highly potent, selective, and partial agonist of serotonin subtype 4 receptor (Ki= 10.4 nM). Also acts as a potent, mixed type, competitive inhibitor of AChE (IC₅₀ = 16 nM).

Donecopride Fumarate - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-HT4R Agonist, AChE Inhibitor, MR31147, Serotonin receptor 5-HT4R agonist

Primary Target: 5-HT4R
532383
  
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₂H₃₃ClN₂O₂·C₄H₄O₄·xH₂O
Description
Overview

This product has been discontinued.



A cell permeable, brain penetrating piperidin-4-yl-propanone compound that that acts as a highly potent, selective and partial agonist of serotonin subtype 4 receptor ((h)5-HT4R; Ki = 10.4 nM and 48% efficacy compared to 5-HT control). Also acts as a potent, mixed type, competitive inhibitor of acetylcholinesterase (IC50 = 16 nM for human AChE) and offers selectivity over butyrylcholinesterase (IC50 = 3.5 µM). With respect to 5-HT2BR, it behaves like an inverse agonist (Ki = 1.6 nM). Promotes sAPPα secretion in COS-7 cells transiently expressing 5-HT4R (EC50 = 11.3 nM) and is shown to have a precognitive effect in murine model where it significantly improves discrimination index (6.3 vs -.0.22 in control mice; 0.3 mg/kg).

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Catalogue Number532383
Brand Family Calbiochem®
Synonyms5-HT4R Agonist, AChE Inhibitor, MR31147, Serotonin receptor 5-HT4R agonist
References
ReferencesLecoutey, C., et al. 2014. Proc. Natl. Acad. Sci. USA 111, E3825.
Product Information
FormOff-white powder
Hill FormulaC₂₂H₃₃ClN₂O₂·C₄H₄O₄·xH₂O
Chemical formulaC₂₂H₃₃ClN₂O₂·C₄H₄O₄·xH₂O
Hygroscopic Hygroscopic
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary Target5-HT4R
Primary Target K<sub>i</sub>10.4 nM
Secondary targetAChE
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
532383 0

Documentation

Donecopride Fumarate - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Lecoutey, C., et al. 2014. Proc. Natl. Acad. Sci. USA 111, E3825.

Brochure

Title
Neuroscience Solutions for productive research

Technical Info

Title
Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
White Paper: Further considerations of antibody validation and usage.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-March-2015 JSW
Synonyms5-HT4R Agonist, AChE Inhibitor, MR31147, Serotonin receptor 5-HT4R agonist
DescriptionA cell permeable, brain penetrating piperidin-4-yl-propanone compound that that acts as a highly potent, selective and partial agonist of serotonin subtype 4 receptor ((h)5-HT4R; Ki = 10.4 nM and 48% efficacy compared to 5-HT control). Also acts as a potent, mixed type, competitive inhibitor of acetylcholinesterase (IC50 = 16 nM for human AChE) and offers selectivity over butyrylcholinesterase (IC50 = 3.5 µM). With respect to 5-HT2BR, it behaves like an inverse agonist (Ki = 1.6 nM). Promotes sAPPα secretion in COS-7 cells transiently expressing 5-HT4R (EC50 = 11.3 nM) and is shown to have a precognitive effect in murine model where it significantly improves discrimination index (6.3 vs -.0.22 in control mice; 0.3 mg/kg).
FormOff-white powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₂H₃₃ClN₂O₂·C₄H₄O₄·xH₂O
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesLecoutey, C., et al. 2014. Proc. Natl. Acad. Sci. USA 111, E3825.