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263275 Desmosine

A novel quaternary pyridinium poly-amino acid present in elastin.

Desmosine MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
263275
  
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Overview

Replacement Information
Description
OverviewA novel quaternary pyridinium poly-amino acid present in elastin. Suggested to be responsible for the cross-linking of elastin leading to the formation of insoluble fibers. Urinary excretion of desmosine is a useful indicator of elastin breakdown resulting from increased elastase activity.
Catalogue Number263275
Brand Family Calbiochem®
References
ReferencesAkagawa, M., and Suyama, K. 2000. Connect. Tissue Res. 41, 131.
Bode, D.C., et al. 2000. Pulm. Pharmacol. Therap. 13, 175.
Viglio, S., et al. 2000. Eur. Respir. J. 15, 1039.
Davis, N.R., and Anwar, R.A. 1970. J. Am. Chem. Soc. 92, 3778.
Thomas, J., et al. 1963. Nature 200, 651.
Product Information
ATP CompetitiveN
FormLyophilized
Hill FormulaC₂₄H₃₉N₅O₈
Chemical formulaC₂₄H₃₉N₅O₈
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCross-linking of elastin
Purity≥99% by TLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
263275 0

Documentation

Desmosine SDS

Title

Safety Data Sheet (SDS) 

Desmosine Certificates of Analysis

TitleLot Number
263275

References

Reference overview
Akagawa, M., and Suyama, K. 2000. Connect. Tissue Res. 41, 131.
Bode, D.C., et al. 2000. Pulm. Pharmacol. Therap. 13, 175.
Viglio, S., et al. 2000. Eur. Respir. J. 15, 1039.
Davis, N.R., and Anwar, R.A. 1970. J. Am. Chem. Soc. 92, 3778.
Thomas, J., et al. 1963. Nature 200, 651.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-June-2008 RFH
DescriptionA novel quaternary pyridinium poly-amino acid present in elastin. Suggested to be responsible for the cross-linking of elastin leading to the formation of insoluble fibers. Urinary excretion of desmosine is a useful indicator of elastin breakdown resulting from increased elastase activity. Absorption max: 268 nm.
FormLyophilized
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₄H₃₉N₅O₈
Structure formulaStructure formula
Purity≥99% by TLC
SolubilityH₂O (10 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesAkagawa, M., and Suyama, K. 2000. Connect. Tissue Res. 41, 131.
Bode, D.C., et al. 2000. Pulm. Pharmacol. Therap. 13, 175.
Viglio, S., et al. 2000. Eur. Respir. J. 15, 1039.
Davis, N.R., and Anwar, R.A. 1970. J. Am. Chem. Soc. 92, 3778.
Thomas, J., et al. 1963. Nature 200, 651.