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251800 Daunorubicin, Hydrochloride - CAS 23541-50-6 - Calbiochem

Potent cell-permeable anticancer agent whose potential target site may be mitochondrial cytochrome c oxidase.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Daunomycin, HCl

Primary Target: DNA synthesis, RNA synthesis
251800
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
23541-50-6C₂₇H₂₉NO₁₀ · HCl
Description
OverviewPotent cell-permeable anticancer agent whose potential target site may be mitochondrial cytochrome c oxidase. Has been shown to inhibit RNA and DNA synthesis. Inhibits eukaryotic topoisomerases I and II. Induces DNA single-strand breaks. Also induces apoptosis in HeLa S3 tumor cells.
Catalogue Number251800
Brand Family Calbiochem®
SynonymsDaunomycin, HCl
References
ReferencesFriedenberg, W.R., et al. 1995. Am. J. Clin. Oncol. 18, 105.
Papadopoulou, L.C., and Tsiftsoglou, A.S. 1993. Cancer Res. 53, 1072.
Skladanowski, A., and Konopa, J. 1993. Biochem. Pharmacol. 46, 375.
Wolff, M., and Jelkmann, W. 1993. Ann. Hematol. 66, 27.
Bellec, F., et al. 1992. Flow Cytometry 13, 880.
Product Information
CAS number23541-50-6
ATP CompetitiveN
FormRed crystalline solid
Hill FormulaC₂₇H₂₉NO₁₀ · HCl
Chemical formulaC₂₇H₂₉NO₁₀ · HCl
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetDNA synthesis, RNA synthesis
PurityPotency: ≥840 µg/mg
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSHB7878000
Safety Information
R PhraseR: 22-40-42/43

Harmful if swallowed.
Limited evidence of a carcinogenic effect.
May cause sensitization by inhalation and skin contact.
S PhraseS: 22-36/37-45

Do not breathe dust.
Wear suitable protective clothing and gloves.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful & Carcinogenic / Teratogenic
Storage +15°C to +30°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 1 month at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
251800 0

Documentation

Daunorubicin, Hydrochloride - CAS 23541-50-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Daunorubicin, Hydrochloride - CAS 23541-50-6 - Calbiochem Certificates of Analysis

TitleLot Number
251800

References

Reference overview
Friedenberg, W.R., et al. 1995. Am. J. Clin. Oncol. 18, 105.
Papadopoulou, L.C., and Tsiftsoglou, A.S. 1993. Cancer Res. 53, 1072.
Skladanowski, A., and Konopa, J. 1993. Biochem. Pharmacol. 46, 375.
Wolff, M., and Jelkmann, W. 1993. Ann. Hematol. 66, 27.
Bellec, F., et al. 1992. Flow Cytometry 13, 880.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-June-2008 RFH
SynonymsDaunomycin, HCl
DescriptionPotent cell-permeable anticancer agent whose potential target site may be mitochondrial cytochrome C oxidase. Has been shown to inhibit RNA and DNA synthesis and to intercalate into DNA. Inhibits eukaryotic topoisomerase I and II. Induces DNA single strand breaks. Induces apoptosis in HeLaS3 tumor cells.
FormRed crystalline solid
CAS number23541-50-6
RTECSHB7878000
Chemical formulaC₂₇H₂₉NO₁₀ · HCl
Structure formulaStructure formula
PurityPotency: ≥840 µg/mg
SolubilityAqueous buffers, H₂O, or Methanol
Storage +15°C to +30°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 1 month at 4°C.
Toxicity Harmful & Carcinogenic / Teratogenic
Merck USA index14, 2832
ReferencesFriedenberg, W.R., et al. 1995. Am. J. Clin. Oncol. 18, 105.
Papadopoulou, L.C., and Tsiftsoglou, A.S. 1993. Cancer Res. 53, 1072.
Skladanowski, A., and Konopa, J. 1993. Biochem. Pharmacol. 46, 375.
Wolff, M., and Jelkmann, W. 1993. Ann. Hematol. 66, 27.
Bellec, F., et al. 1992. Flow Cytometry 13, 880.