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251650 Damnacanthal - CAS 477-84-9 - Calbiochem

A cell-permeable, potent, reversible, and selective inhibitor of p56lck tyrosine kinase.

Damnacanthal - CAS 477-84-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-Hydroxy-1-methoxyanthraquinone-2-aldehyde

Primary Target: p56lck autophosphorylation
251650
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Overview

Key Spec Table

CAS #Empirical Formula
477-84-9C₁₆H₁₀O₅

Products

Catalogue NumberPackaging Qty/Pack
251650-1MG Plastic ampoule 1 mg
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Description
OverviewA cell-permeable, potent, reversible, and selective inhibitor of p56lck tyrosine kinase. Inhibits p56lck autophosphorylation (IC50 = 17 nM) and phosphorylation of an exogenous peptide by p56lck (IC50 = 620 nM). Exhibits over 100-fold greater selectivity for p56lck over PKA and PKC, 40-fold greater selectivity for p56lck over EGF receptor kinase, c-ErbB2, insulin receptor kinase, and PDGF receptor kinase, and 7 - 20-fold greater selectivity for p56lck over p60src and p59fyn. Inhibition of p56lck is not significantly affected by the presence of sulfhydryl reagents. Also known to have antimalarial properties and to reverse the phenotype of ras-transformed cells.
Catalogue Number251650
Brand Family Calbiochem®
Synonyms3-Hydroxy-1-methoxyanthraquinone-2-aldehyde
References
ReferencesFaltynek, C.R., et al. 1995. Biochemistry 34, 12404.
Hiramatsu, T., et al. 1993. Cancer Lett. 73, 161.
Koumaglo, K., et al. 1992. Planta Med. 58, 533.
Product Information
CAS number477-84-9
ATP CompetitiveN
FormOrange-yellow solid
Hill FormulaC₁₆H₁₀O₅
Chemical formulaC₁₆H₁₀O₅
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary Targetp56lck autophosphorylation
Primary Target IC<sub>50</sub>17 nM against p56lck autophosphorylation
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
251650-1MG 04055977198553