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574215 D,L-Sulforaphane - CAS 4478-93-7 - Calbiochem

574215
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Overview

Key Spec Table

CAS #Empirical Formula
4478-93-7C₆H₁₁NOS₂

Products

Catalogue NumberPackaging Qty/Pack
574215-25MG Plastic ampoule 25 mg
Description
OverviewAn isothiocyanate isolated from broccoli that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture. It has been shown to be an effective agent in prevention of chemically-induced mammary tumors in rats. It also inhibits the phase I cytochrome P450 isoenzymes 2E1 and IA2 which have been associated with the activation of carcinogens. The induction of phase II enzymes is mediated by mitogen-activated protein kinase (MAPK) pathway.
Catalogue Number574215
Brand Family Calbiochem®
Synonyms1-Isothiocyanato-4-(methylsulfinyl)butane, R,S-Sulforaphane
References
ReferencesGamet-Payrastre, L., et al. 2000. Cancer Res. 60, 1426.
Yu, R., et al. 2000. J. Biol. Chem. 275, 2322.
Yu, R., et al. 1999. J. Biol. Chem. 274, 27545.
Barcelo, S., et al. 1998. Mutat. Res. 402, 111.
Maheo, K., et al. 1997. Cancer Res. 57, 3649.
Zhang, Y., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3147.
Zhang, Y., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 2399.
Product Information
CAS number4478-93-7
ATP CompetitiveN
FormSlight yellow liquid
Hill FormulaC₆H₁₁NOS₂
Chemical formulaC₆H₁₁NOS₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationD,L-Sulforaphane, CAS 4478-93-7, is an anti-tumor agent that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture.
Biological Information
Primary TargetPotent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture
Purity≥98% by UPLC
Physicochemical Information
Cell permeableN
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze DMSO stock solutions (-20°C) and ethanol stock solutions (-70°C). DMSO stock solutions are stable for up to 3 months at -20°C and ethanol stock solutions are stable for up to 3 months at -70°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
574215-25MG 04055977189568