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252801 DGAT-1 Inhibitor, A 922500 - CAS 959122-11-3 - Calbiochem

The DGAT-1 Inhibitor, A 922500, also referenced under CAS 959122-11-3, controls the biological activity of DGAT-1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
252801
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
959122-11-3C₂₆H₂₄N₂O₄
Description
OverviewAn orally, bioavailable human and mouse diacylglycerol acyltransferase DGAT-1 inhibitor (IC50 = 9nM and 22 nM, respectively), which may target DGAT-2 (IC50 = 53 uM) and the phylogenetic family members acyl coenzyme A cholesterol acyltransferase-1 and -2 (IC50 = 296 uM) with equal or less potencies. In vivo activities indicate an effective reduction in serum triglycerides, FFA concentrations, and total cholesterol by 53%, 55% and 25%, respectively, compared to baseline, when administered orally at 3 mg/kg daily dosages in Dyslipidemic Hamsters. Similar reductions in triglyceride and FFA concentrations were shown in Zucker fatty rats.
Catalogue Number252801
Brand Family Calbiochem®
References
ReferencesKing, A.J., et al. 2009. J. Pharmacol. Exp. Ther. 330, 526.
Product Information
CAS number959122-11-3
FormLight yellow solid
Hill FormulaC₂₆H₂₄N₂O₄
Chemical formulaC₂₆H₂₄N₂O₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Regulatory Review
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
252801 0

Documentation

DGAT-1 Inhibitor, A 922500 - CAS 959122-11-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

DGAT-1 Inhibitor, A 922500 - CAS 959122-11-3 - Calbiochem Certificates of Analysis

TitleLot Number
252801

References

Reference overview
King, A.J., et al. 2009. J. Pharmacol. Exp. Ther. 330, 526.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-December-2015 JSW
DescriptionAn orally, bioavailable human and mouse diacylglycerol acyltransferase DGAT-1 inhibitor (IC50 = 9nM and 22 nM, respectively), which may target DGAT-2 (IC50 = 53 µM) and the phylogenetic family members acyl coenzyme A cholesterol acyltransferase-1 and -2 (IC50 = 296 µM) with equal or less potencies. In vivo activities indicate an effective reduction in serum triglycerides, FFA concentrations, and total cholesterol by 53%, 55% and 25%, respectively, compared to baseline, when administered orally at 3 mg/kg daily dosages in Dyslipidemic Hamsters. Similar reductions in triglyceride and FFA concentrations were shown in Zucker fatty rats.
FormLight yellow solid
CAS number959122-11-3
Chemical formulaC₂₆H₂₄N₂O₄
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Regulatory Review
ReferencesKing, A.J., et al. 2009. J. Pharmacol. Exp. Ther. 330, 526.