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454863 D-erythro-MAPP - CAS 143492-38-0 - Calbiochem

A synthetic analog of ceramide.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (1S,2R)-D-erythro-2-(N-Myristoylamino)-1-phenyl-1-propanol, AC Inhibitor II, Acid Ceramidase Inhibitor II, D-e-MAPP

454863
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
143492-38-0C₂₃H₃₉NO₂
Description
OverviewA synthetic analog of ceramide. Shown to selectively inhibit alkaline ceramidase both in vitro and in HL-60 cells (IC50 = 1-5 µM for alkaline ceramidase versus IC50 > 500 µM for acid ceramidase). This inhibition results in over 3-fold increase in endogenous ceramide in treated cells due to lack of breakdown of ceramide to sphingosine.
Catalogue Number454863
Brand Family Calbiochem®
Synonyms(1S,2R)-D-erythro-2-(N-Myristoylamino)-1-phenyl-1-propanol, AC Inhibitor II, Acid Ceramidase Inhibitor II, D-e-MAPP
References
ReferencesBielawska, A., et al. 1996. J. Biol. Chem. 271, 12646.
Hannun, Y.A. 1996. Science 274, 1855.
Product Information
CAS number143492-38-0
ATP CompetitiveN
FormSolid
Hill FormulaC₂₃H₃₉NO₂
Chemical formulaC₂₃H₃₉NO₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetAlkaline ceramidase
Primary Target IC<sub>50</sub>1-5 µM for alkaline ceramidase versus > 500 µM for acid ceramidase
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
454863 0

Documentation

D-erythro-MAPP - CAS 143492-38-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

D-erythro-MAPP - CAS 143492-38-0 - Calbiochem Certificates of Analysis

TitleLot Number
454863

References

Reference overview
Bielawska, A., et al. 1996. J. Biol. Chem. 271, 12646.
Hannun, Y.A. 1996. Science 274, 1855.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-September-2019 JSW
Synonyms(1S,2R)-D-erythro-2-(N-Myristoylamino)-1-phenyl-1-propanol, AC Inhibitor II, Acid Ceramidase Inhibitor II, D-e-MAPP
DescriptionA synthetic analog of ceramide. Shown to selectively inhibit alkaline ceraminidase both in vitro and in HL-60 cells (IC50 = 1-5 µM for alkaline ceramides versus IC50 >500 µM for acid ceraminidase). This inhibition results in and over 3-fold increase in endogenous ceramide in treated cells due to a lack of breakdown of ceramide to sphingosine.
FormSolid
CAS number143492-38-0
Chemical formulaC₂₃H₃₉NO₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityEthanol (5 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesBielawska, A., et al. 1996. J. Biol. Chem. 271, 12646.
Hannun, Y.A. 1996. Science 274, 1855.