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538244 Cyclorasin 9A5 - Calbiochem

Cyclorasin 9A5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Cyclic Ras Inhibitor

Primary Target: Ras-GTP
538244
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₇₅H₁₀₈FN₂₅O₁₃

Products

Catalogue NumberPackaging Qty/Pack
5.38244.0001 Glass bottle 5 mg
Description
OverviewA cell-permeable 11-mer cyclic peptide that displays high-affinity towards Ras-GTP (IC50 = 120 nM for K-Ras G12V) and inhibits Ras signaling. Shown to readily localize into cytoplasm and directly bind to Ras-GTP near the effector-binding site in a reversible manner. Dose-dependently impairs Ras-B-Raf interaction and blocks EGF-stimulated activation of Akt, MEK & ERK (IC50 = 3.1 µM in H1299 cells). Efficiently induces lung cancer cell growth arrest and triggers apoptosis (LD50 = 3.0 µM in H1299). NOTE: ala = D-Alanine; nal = D-2-naphthylalanine; nle = D-norleucine; Fpa = L-4-Fluorophenylalanine

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number538244
Brand Family Calbiochem®
SynonymsCyclic Ras Inhibitor
References
ReferencesUpadhyaya. P., et al. 2015. Angew. Chem. Int. Ed. 54, 7602.
Product Information
FormOff-white solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₇₅H₁₀₈FN₂₅O₁₃
Chemical formulaC₇₅H₁₀₈FN₂₅O₁₃
Hygroscopic Hygroscopic
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetRas-GTP
Primary Target IC<sub>50</sub>120 nM for K-Ras G12V
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Peptide Sequencecyclo(-Trp-Thr-ala-Arg-Arg-Arg-nal-Arg-Fpa-nle-Gln)
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5.38244.0001 04054839119446

Documentation

Cyclorasin 9A5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Upadhyaya. P., et al. 2015. Angew. Chem. Int. Ed. 54, 7602.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-July-2017 JSW
SynonymsCyclic Ras Inhibitor
DescriptionA cell-permeable 11-mer cyclic peptide that displays high-affinity towards Ras-GTP (IC50 = 120 nM for K-Ras G12V) and inhibits Ras signaling. Shown to readily localize into cytoplasm and directly bind to Ras-GTP near the effector-binding site in a reversible manner. Dose-dependently impairs Ras-B-Raf interaction and blocks EGF-stimulated activation of Akt, MEK & ERK (IC50 = 3.1 µM in H1299 cells). Efficiently induces lung cancer cell growth arrest and triggers apoptosis (LD50 = 3.0 µM in H1299). NOTE: ala = D-Alanine; nal = D-2-naphthylalanine; nle = D-norleucine; Fpa = L-4-Fluorophenylalanine
FormOff-white solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₇₅H₁₀₈FN₂₅O₁₃
Peptide Sequencecyclo(-Trp-Thr-ala-Arg-Arg-Arg-nal-Arg-Fpa-nle-Gln)
Purity≥98% by HPLC
SolubilityH₂O (100 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesUpadhyaya. P., et al. 2015. Angew. Chem. Int. Ed. 54, 7602.