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220557 Chlorhexidine, Dihydrochloride

Chlorhexidine, Dihydrochloride MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1,6-bis[Nʹ-(p-Chlorophenyl)-N⁵-biguanido]hexane, 2HCl, CHX

Primary Target: MMP-2, MMP-9
220557
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
3697-42-5C₂₂H₃₀Cl₂N₁₀ · 2HCl
Description
Overview

This product has been discontinued.





An anti-microbial agent that acts as an inhibitor of MMP-2 and MMP-9; however, MMP-2 is more sensitive to chlorhexidine than MMP-9. Inhibits the collagenase activity of MMP-8 released by PMA-triggered polymorphonuclear leukocytes (PMNs) in a dose-dependent manner. CHX may possibly act through a cation-chelating mechanism.
Note: presence of CaCl2 in the medium blocks the inhibitory activity of CHX.
Catalogue Number220557
Brand Family Calbiochem®
Synonyms1,6-bis[Nʹ-(p-Chlorophenyl)-N⁵-biguanido]hexane, 2HCl, CHX
References
ReferencesGendron, R., et al. 1999. Clin. Diagn. Lab. Immunol. 6, 437.
Product Information
CAS number3697-42-5
FormWhite solid
Hill FormulaC₂₂H₃₀Cl₂N₁₀ · 2HCl
Chemical formulaC₂₂H₃₀Cl₂N₁₀ · 2HCl
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetMMP-2, MMP-9
Secondary targetMMP-8 collagenase activity
Purity≥95% by titration
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSXA5285000
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
220557 0

Documentation

Chlorhexidine, Dihydrochloride SDS

Title

Safety Data Sheet (SDS) 

Chlorhexidine, Dihydrochloride Certificates of Analysis

TitleLot Number
220557

References

Reference overview
Gendron, R., et al. 1999. Clin. Diagn. Lab. Immunol. 6, 437.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-April-2008 RFH
Synonyms1,6-bis[Nʹ-(p-Chlorophenyl)-N⁵-biguanido]hexane, 2HCl, CHX
DescriptionAn antimicrobial agent. Acts as an inhibitor of MMP-2 and MMP-9, however, MMP-2 is more sensitive to chlorhexidine than MMP-9. Inhibits the collagenolytic activity of MMP-8 released by PMA-triggered polymorphonuclear leukocytes (PMNs) in a dose-dependent manner. CHX may possibly act through a cation-chelating mechanism.

Note: Presence of CaCl2 in the medium blocks the inhibitory activity of CHX.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number3697-42-5
RTECSXA5285000
Chemical formulaC₂₂H₃₀Cl₂N₁₀ · 2HCl
Structure formulaStructure formula
Purity≥95% by titration
SolubilityDMSO. It takes about 15 min. to completely dissolve the solid at 1 mg/ml in DMSO. Requires more time for complete solubilization at higher concentrations.
Storage +2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
Merck USA index14, 2091
ReferencesGendron, R., et al. 1999. Clin. Diagn. Lab. Immunol. 6, 437.