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238804 Cdk2 Inhibitor IV, NU6140 - CAS 444723-13-1 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(6-Cyclohexylmethoxy-9H-purin-2-ylamino)-N,N-diethylbenzamide, Cdk7 Inhibitor II

Primary Target: Cdk1/cyclin B
238804
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
444723-13-1C₂₃H₃₀N₆O₂
Description
Overview

This product has been discontinued.



A highly cell-permeable purine compound that displays anticancer properties and acts as a selective and ATP-competitive inhibitor of Cdks (IC50 = 6.6 µM, 0.41 µM, 5.5 µM, 15 µM and 3.9 µM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk4/cyclin D, Cdk5/p25 and Cdk7/cyclin H, respectively). Shown to cause cell cycle arrest at the G2/M phase and induce apoptosis by activating caspases and down-regulation survivin. Synergistically potentiates paclitaxel cytotoxicity and apoptotic response in HeLa and OAW42 cells.
Catalogue Number238804
Brand Family Calbiochem®
Synonyms4-(6-Cyclohexylmethoxy-9H-purin-2-ylamino)-N,N-diethylbenzamide, Cdk7 Inhibitor II
References
ReferencesPennati, M., et al. 2005. Mol. Cancer Ther. 4, 1328.
Product Information
CAS number444723-13-1
ATP CompetitiveY
FormOff-white solid
Hill FormulaC₂₃H₃₀N₆O₂
Chemical formulaC₂₃H₃₀N₆O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCdk1/cyclin B
Primary Target IC<sub>50</sub>6.6 µM, 0.41 µM, 5.5 µM, 15 µM and 3.9 µM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk4/cyclin D, Cdk5/p25 and Cdk7/cyclin H, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
238804 0

Documentation

Cdk2 Inhibitor IV, NU6140 - CAS 444723-13-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Cdk2 Inhibitor IV, NU6140 - CAS 444723-13-1 - Calbiochem Certificates of Analysis

TitleLot Number
238804

References

Reference overview
Pennati, M., et al. 2005. Mol. Cancer Ther. 4, 1328.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-October-2007 JSW
Synonyms4-(6-Cyclohexylmethoxy-9H-purin-2-ylamino)-N,N-diethylbenzamide, Cdk7 Inhibitor II
DescriptionA highly cell-permeable purine compound that displays anticancer properties and acts as a selective and ATP-competitive inhibitor of Cdks (IC50 = 6.6 µM, 0.41 µM, 5.5 µM, 15 µM and 3.9 µM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk4/cyclin D, Cdk5/p25 and Cdk7/cyclin H, respectively). Shown to cause cell cycle arrest at the G2/M phase and induce apoptosis by activating caspases and down-regulation survivin. Synergistically potentiates paclitaxel cytotoxicity and apoptotic response in HeLa and OAW42 cells.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number444723-13-1
Chemical formulaC₂₃H₃₀N₆O₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesPennati, M., et al. 2005. Mol. Cancer Ther. 4, 1328.