Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

217707 Cdc7/Cdk9 Inhibitor - CAS 845714-00-3 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(Pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridinone, PHA-767491, Chk2 Inhibitor VI

217707
  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
845714-00-3C₁₂H₁₁N₃O
Description
Overview

This product has been discontinued.



A cell-permeable pyrrolopyridinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of Cdc7 and Cdk9 (IC50 = 10 and 34 nM, respectively) with good selectivity over a panel of 31 other kinases, including GSK-3β, Cdk2, Cdk1, Cdk5, MK-2, Plk1, and Chk2 (IC50 = 0.22, 0.24, 0.25, 0.46, 0.47, 0.98, and 1.1 µM, respectively). Cellular treatment of PHA76749 results in a prevention of the activation of DNA replication origins without the inhibition of replication fork progression. Shown to inhibit the proliferation of 61 cell lines in vitro (IC50 ≤ 10 µM) and exhibit antitumor activity in both mice and rats in vivo.
Catalogue Number217707
Brand Family Calbiochem®
Synonyms2-(Pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridinone, PHA-767491, Chk2 Inhibitor VI
References
ReferencesMontagnoli, A., et al. 2008. Nat Chem Biol. 4, 357.
Vanotti, E., et al. 2008. J. Med. Chem. 51, 487.
Anderson, D.R., et al. 2007. J. Med. Chem. 50, 2647.
Product Information
CAS number845714-00-3
FormPink solid
Hill FormulaC₁₂H₁₁N₃O
Chemical formulaC₁₂H₁₁N₃O
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥90% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
217707 0

Documentation

Cdc7/Cdk9 Inhibitor - CAS 845714-00-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Cdc7/Cdk9 Inhibitor - CAS 845714-00-3 - Calbiochem Certificates of Analysis

TitleLot Number
217707

References

Reference overview
Montagnoli, A., et al. 2008. Nat Chem Biol. 4, 357.
Vanotti, E., et al. 2008. J. Med. Chem. 51, 487.
Anderson, D.R., et al. 2007. J. Med. Chem. 50, 2647.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-April-2011 RFH
Synonyms2-(Pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridinone, PHA-767491, Chk2 Inhibitor VI
DescriptionA cell-permeable pyrrolopyridinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of Cdc7 and Cdk9 (IC50 = 10 and 34 nM, respectively) with good selectivity over a panel of 31 other kinases, including GSK-3β, Cdk2, Cdk1, Cdk5, MK-2, Plk1, and Chk2 (IC50 = 0.22, 0.24, 0.25, 0.46, 0.47, 0.98, and 1.1 µM, respectively). Cellular treatment of PHA76749 results in a prevention of the activation of DNA replication origins without the inhibition of replication fork progression. Shown to inhibit the proliferation of 61 cell lines in vitro (IC50 ≤10 µM) and exhibit antitumor activity in both mice and rats in vivo.
FormPink solid
Intert gas (Yes/No) Packaged under inert gas
CAS number845714-00-3
Chemical formulaC₁₂H₁₁N₃O
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityDMSO (25 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesMontagnoli, A., et al. 2008. Nat Chem Biol. 4, 357.
Vanotti, E., et al. 2008. J. Med. Chem. 51, 487.
Anderson, D.R., et al. 2007. J. Med. Chem. 50, 2647.