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218825 Caspase Inhibitor Set IV - Calbiochem

The Caspase Inhibitor Set IV controls the biological activity of Caspase. This collection of small molecule/inhibitor is primarily used for Cancer applications.

Caspase Inhibitor Set IV - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: pan-caspase
218825
  
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
OverviewA set of four ready-to-use cell-permeable, irreversible inhibitors of various caspase-family proteases and a negative control apoptosis inducer. Each vial contains 25 µl of a 10 mM solution in DMSO of Caspase-3 Inhibitor II, Z-DEVD-FMK (Cat. No. 264155); Caspase-8 Inhibitor II, Z-IETD-FMK (Cat. No. 218759); Caspase-9 Inhibitor I, Z-LEHD-FMK (Cat. No 218761); general caspase inhibitor, Z-VAD-FMK (Cat. No. 627610); the negative control Z-FA-FMK (Cat. No. 342000), and an aqueous solution (100 µl, 6.1 µg/µl) of an apoptosis inducer, Doxorubicin, Hydrochloride (Cat. No. 324380). Supplied with a data sheet.
Catalogue Number218825
Brand Family Calbiochem®
References
Product Information
ATP CompetitiveN
FormLiquid
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary Targetpan-caspase
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/38-45-46

Irritating to eyes and skin.
May cause cancer.
May cause heritable genetic damage.
S PhraseS: 26-36/37-45-53-23-28

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing and gloves.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Avoid exposure - obtain special instructions before use.
Do not breathe fumes.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Multiple Toxicity Values, refer to MSDS
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
218825 0

Documentation

Caspase Inhibitor Set IV - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Caspase Inhibitor Set IV - Calbiochem Certificates of Analysis

TitleLot Number
218825

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-April-2010 RFH
DescriptionApoptosis is a normal process in development and morphogenesis. Many cells can be activated to undergo apoptosis following the interaction of selected ligands with cell surface receptors. Receptor-mediated apoptosis involves the activation of caspases (cysteine-containing aspartate-specific proteases). A distinctive feature of caspases is the requirement of an aspartic acid residue in the substrate P1 position.

Caspase inhibitors act by binding to the active site of caspases and form either a reversible or an irreversible linkage. Caspase inhibitor design includes a peptide recognition sequence attached to a functional group such as an aldehyde (CHO), chloromethylketone (CMK), fluoromethylketone (FMK), or fluoroacyloxymethylketone (FAOM). Caspase inhibitors with a CHO group are reversible and those with a CMK, FMK, or FAOM group are irreversible and cell-permeable. FMK exhibits slightly less reactivity than CMK and therefore is more specific for the enzyme being inhibited.
FormLiquid
Intert gas (Yes/No) Packaged under inert gas
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Toxicity Multiple Toxicity Values, refer to MSDS