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218765 Caspase-9 Substrate I, Fluorogenic - CAS 210345-03-2 - Calbiochem

A fluorogenic substrate for caspase-9 (ICE-LAP6, Mch6).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Ac-LEHD-AFC

218765
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Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
218765-1MG Glass bottle 1 mg
218765-5MG Plastic ampoule 5 mg
Description
OverviewA fluorogenic substrate for caspase-9 (ICE-LAP6, Mch6). May also act as a substrate for caspase-4 and caspase-5. Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore.
Catalogue Number218765
Brand Family Calbiochem®
SynonymsAc-LEHD-AFC
References
ReferencesIto, A., et al. 1999. Biochim. Biophys. Acta 1452, 263.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.
Product Information
CAS number210345-03-2
ATP CompetitiveN
FormWhite solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₃₃H₃₈F₃N₇O₁₁
Chemical formulaC₃₃H₃₈F₃N₇O₁₁
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetA fluorogenic substrate for caspase-9
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Emission max.
Excitation max.
Peptide SequenceAc-Leu-Glu-His-Asp-AFC
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
218765-1MG 07790788060237
218765-5MG 04055977218671

Documentation

Caspase-9 Substrate I, Fluorogenic - CAS 210345-03-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Caspase-9 Substrate I, Fluorogenic - CAS 210345-03-2 - Calbiochem Certificates of Analysis

TitleLot Number
218765

References

Reference overview
Ito, A., et al. 1999. Biochim. Biophys. Acta 1452, 263.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-June-2008 RFH
SynonymsAc-LEHD-AFC
DescriptionA fluorogenic substrate for caspase-9 (ICE-LAP6, Mch6). Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore (excitation maximum: ~400 nm; emission maximum: ~505 nm).
FormWhite solid
FormulationSupplied as a trifluoroacetate salt.
CAS number210345-03-2
Chemical formulaC₃₃H₃₈F₃N₇O₁₁
Peptide SequenceAc-Leu-Glu-His-Asp-AFC
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from moisture
Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesIto, A., et al. 1999. Biochim. Biophys. Acta 1452, 263.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.