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218826 Caspase-3/7 Inhibitor I - CAS 220509-74-0 - Calbiochem

The Caspase-3/7 Inhibitor I, also referenced under CAS 220509-74-0, controls the biological activity of Caspase-3/7. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-[(S)-(+)-2-(Methoxymethyl)pyrrolidino]sulfonylisatin

Primary Target: caspase-3
218826
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
220509-74-0C₁₄H₁₆N₂O₅S
Description
OverviewA potent, cell-permeable, and specific, reversible inhibitor of caspase-3 (Ki = 60 nM) and caspase-7 (Ki = 170 nM).
Catalogue Number218826
Brand Family Calbiochem®
Synonyms5-[(S)-(+)-2-(Methoxymethyl)pyrrolidino]sulfonylisatin
References
ReferencesLee, D., et al. 2001. J. Med. Chem. 44, 2015.
Lee, D., et al. 2000. J. Biol. Chem. 275, 16007.
Product Information
CAS number220509-74-0
ATP CompetitiveN
FormYellow solid
Hill FormulaC₁₄H₁₆N₂O₅S
Chemical formulaC₁₄H₁₆N₂O₅S
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetcaspase-3
Primary Target K<sub>i</sub> 60 nM, 170 nM, against caspase-3 and caspase-7, respectively
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Peptide Sequence5-[(S)-(+)-2-(Methoxymethyl)pyrrolidino]sulfonylisatin
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
218826 0

Documentation

Caspase-3/7 Inhibitor I - CAS 220509-74-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Caspase-3/7 Inhibitor I - CAS 220509-74-0 - Calbiochem Certificates of Analysis

TitleLot Number
218826

References

Reference overview
Lee, D., et al. 2001. J. Med. Chem. 44, 2015.
Lee, D., et al. 2000. J. Biol. Chem. 275, 16007.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-February-2014 JSW
Synonyms5-[(S)-(+)-2-(Methoxymethyl)pyrrolidino]sulfonylisatin
DescriptionA potent, reversible, isatin sulfonamide-based inhibitor of caspase-3 (KI(app) = 60 nM) and caspase-7 (KI(app) = 170 nM). Inhibits caspase-9 to a lesser extent (Ki(app) = 3.1 µM). Has only a trivial effect (Ki(app) >25 mM) on the activities of caspase-1, caspase-2, caspase-4, caspase-6, and caspase-8. Reported to inhibit apoptosis in camptothecin treated Jurkat cells (IC50 ~50 µM). Also reported to inhibit apoptosis in chondrocytes (44% inhibition at 10 µM and 98% inhibition at 50 µM). Selectivity for caspases 3 and 7 involves unique hydrophobic residues in the S2 pocket surrounding the catalytic cysteine residue.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number220509-74-0
Chemical formulaC₁₄H₁₆N₂O₅S
Peptide Sequence5-[(S)-(+)-2-(Methoxymethyl)pyrrolidino]sulfonylisatin
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (200 mg/ml) or Methanol (10 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesLee, D., et al. 2001. J. Med. Chem. 44, 2015.
Lee, D., et al. 2000. J. Biol. Chem. 275, 16007.