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218713 Casein Kinase II Inhibitor IV - CAS 863598-09-8 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(3-(2-(3,4,5-Trimethoxy-phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)propionitrile, Casein Kinase II Inhibitor IV, Keratinocyte Differentiation Inducer

218713
  
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Overview

Key Spec Table

CAS #Empirical Formula
863598-09-8C₂₄H₂₃N₅O₃
Description
Overview

This product has been discontinued.



A cell-permeable pyrrolo-pyrimidone compound that acts as a potent, ATP-competitive inhibitor of casein kinase II (IC50 = 9 nM) and an effective inducer of normal human keratinocytes (NHEK) differentiation (EC50 = 100 nM). In addition to CKII, it is also shown to interact, directly or indirectly, with cellular TANK-binding Kinase 1 (TBK1) and NIMA-related kinase 9 (NEK9).
Catalogue Number218713
Brand Family Calbiochem®
Synonyms3-(3-(2-(3,4,5-Trimethoxy-phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)propionitrile, Casein Kinase II Inhibitor IV, Keratinocyte Differentiation Inducer
References
ReferencesHong, J., et al. 2007. ACS Chem. Biol. 2, 171.
Product Information
CAS number863598-09-8
FormBeige solid
Hill FormulaC₂₄H₂₃N₅O₃
Chemical formulaC₂₄H₂₃N₅O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥90% by HPLC
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months as supplied.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
218713 0