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14-724M CLK3 Protein, active, 250 µg

Active, N-terminal 6His-tagged, recombinant full length human CLK3, for use in Kinase Assays.

14-724M
250 µg  Also available in 10 μg size (cat#14-724) and in bulk (cat#14-724-K).
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
Catalogue Number14-724M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionCLK3 Protein, active, 250 µg
OverviewN-terminal 6His-tagged, recombinant full length human CLK3
References
Product Information
Quality LevelMQ300
Applications
ApplicationActive, N-terminal 6His-tagged, recombinant full length human CLK3, for use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Sourceexpressed by baculovirus in Sf21 cells
Entrez Gene Number
Entrez Gene SummaryThis gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined. Pseudogenes located on chromosomes 1 and 9 have been found for this gene.
Gene Symbol
  • CLK3
  • FLJ22858
  • clk3
Protein TargetCLK3
Purification MethodNi2+/NTA-agarose
Target Sub-FamilyCMGC
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P49761 # Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates serines, threonines and tyrosines.
SIZE: 638 amino acids; 73515 Da
SUBCELLULAR LOCATION: Nucleus. Cytoplasm (By similarity). Acrosome (By similarity).
PTM: Autophosphorylates on all three types of residues (By similarity).
SIMILARITY: SwissProt: P49761 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. & Contains 1 protein kinase domain.
Molecular Weight63kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by phosphorylation of 500μM PKC Substrate Peptide 2 (Catalog # 12-411)
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C from date of shipment
Packaging Information
Material Size250 µg
Material PackageAlso available in 10 μg size (cat#14-724) and in bulk (cat#14-724-K).
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
14-724M 04053252925443

Documentation

Related Products & Applications

Alternative Packsize

Catalogue Number Description
14-724 CLK3 Protein, active, 10 µg

Product Families

Kinase & Phosphatase Products

Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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Categories

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases