219676 Sigma-AldrichCFTR-F508del Corrector, KM11060 - CAS 774549-97-2 - Calbiochem
A cell-permeable sulfonylpiperazine compound that is shown to boost the surface expression of cellular F508del-CFTR in a time- and dose-dependent manner and help restore CFTR function in F508del-CFTR-expressing cells (Effective concentration 10 µM).
More>> A cell-permeable sulfonylpiperazine compound that is shown to boost the surface expression of cellular F508del-CFTR in a time- and dose-dependent manner and help restore CFTR function in F508del-CFTR-expressing cells (Effective concentration 10 µM). Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 7-Chloro-4-(4-((4-chlorophenyl)sulfonyl)piperazino)quinoline
Recommended Products
Overview
| Replacement Information |
|---|
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 774549-97-2 | C₁₉H₁₇Cl₂N₃O₂S |
| Description | |
|---|---|
| Overview | A cell-permeable sulfonylpiperazine compound that is shown to boost the surface expression of cellular F508del-CFTR in a time- and dose-dependent manner and help restore CFTR function in F508del-CFTR-expressing cells (Effective concentration 10 µM). Evidence indicates that a correction of trafficking at the level of ER coupled with a transient increase of cellular cGMP due to PDEV (Cat. Nos. 524715 and 524738) inhibition as part of the cellular mechanism that accounts for the observed pharmacological effects of KM11060. |
| Catalogue Number | 219676 |
| Brand Family | Calbiochem® |
| Synonyms | 7-Chloro-4-(4-((4-chlorophenyl)sulfonyl)piperazino)quinoline |
| References | |
|---|---|
| References | Robert, R., et al. 2008. Mol. Pharmacol. 73, 478. |
| Product Information | |
|---|---|
| CAS number | 774549-97-2 |
| Form | White solid |
| Hill Formula | C₁₉H₁₇Cl₂N₃O₂S |
| Chemical formula | C₁₉H₁₇Cl₂N₃O₂S |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
|---|
| Biological Information | |
|---|---|
| Purity | ≥97% by HPLC |
| Physicochemical Information |
|---|
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 219676 | 0 |
Documentation
CFTR-F508del Corrector, KM11060 - CAS 774549-97-2 - Calbiochem SDS
| Title |
|---|
CFTR-F508del Corrector, KM11060 - CAS 774549-97-2 - Calbiochem Certificates of Analysis
| Title | Lot Number |
|---|---|
| 219676 |
References
| Reference overview |
|---|
| Robert, R., et al. 2008. Mol. Pharmacol. 73, 478. |