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505308 CDDO-Me - CAS 218600-53-4 - Calbiochem

CDDO-Me - CAS 218600-53-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Bardoxolone methyl, BARD, NSC 713200, Methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate, Nrf Activator V

505308
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
218600-53-4C₃₂H₄₃NO₄
Description
OverviewA cell-permeable, bioavailable synthetic oleanane triterpenoid compound with anti-inflammatory, anti-tumor and cytoprotective properties. Shown to significantly reduce the expression of several inflammatory mediators, including IL-6, IL-10, IL-12, TNFα, Mip1α and others. Reverses high fat diet-induced type 2 diabetes in C57BL/6 mice (3 mg/kg) and improves glucose homeostasis and insulin sensitivity. Down-regulates lipogenic gene expression in hepatocytes. Exhibits anti-proliferative activity in osteosarcoma cells (IC50 = 800, 150, 330, and 170 nM in HOB-c, KHOS, KHOSR2, and U2OS cells, respectively). Enhances the effectiveness of chemotherapeutic agents by inducing intrinsic mitochondrial-dependent apoptotic pathway. Reported to interact with multi cellular targets, namely, Nrf2-Keap1, IKK, JAK-STAT, PPARγ, ErbB2, PTEN, mTOR and Arp3 and covalently modify active site Cys residue via Michael addition.
Catalogue Number505308
Brand Family Calbiochem®
SynonymsBardoxolone methyl, BARD, NSC 713200, Methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate, Nrf Activator V
References
ReferencesLiby, K.T. and Sporn, M.B., 2012. Pharmacol. Rev. 64, 972.
Saha, P.K. et al. 2010. J. Biol. Chem. 285, 40581.
Ryu, K., et al. 2010. BMC Cancer 10, 187.
Liby, K.T., et al. 2007. Nat. Rev. Cancer 7, 357.
Shishodia S., et al. 2006. Clin. Cancer Res. 12, 1828.
Zou, W., et al. 2004. Cancer Res. 64, 7570.
Kim, Y., et al. 2002. J. Biol. Chem. 277, 22320.
Konopleva, M., et al. 2002. Blood 99, 326.
Wang, Y., et al. 2000. Mol Endocrinol. 14, 1550.
Product Information
CAS number218600-53-4
FormWhite solid
Hill FormulaC₃₂H₄₃NO₄
Chemical formulaC₃₂H₄₃NO₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
505308 0

Documentation

CDDO-Me - CAS 218600-53-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Liby, K.T. and Sporn, M.B., 2012. Pharmacol. Rev. 64, 972.
Saha, P.K. et al. 2010. J. Biol. Chem. 285, 40581.
Ryu, K., et al. 2010. BMC Cancer 10, 187.
Liby, K.T., et al. 2007. Nat. Rev. Cancer 7, 357.
Shishodia S., et al. 2006. Clin. Cancer Res. 12, 1828.
Zou, W., et al. 2004. Cancer Res. 64, 7570.
Kim, Y., et al. 2002. J. Biol. Chem. 277, 22320.
Konopleva, M., et al. 2002. Blood 99, 326.
Wang, Y., et al. 2000. Mol Endocrinol. 14, 1550.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-July-2013 JSW
SynonymsBardoxolone methyl, BARD, NSC 713200, Methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate, Nrf Activator V
DescriptionA cell-permeable, bioavailable synthetic oleanane triterpenoid compound with anti-inflammatory, anti-tumor and cytoprotective properties. Shown to significantly reduce the expression of several inflammatory mediators, including IL-6, IL-10, IL-12, TNFα, Mip1α and others. Reverses high fat diet-induced type 2 diabetes in C57BL/6 mice (3 mg/kg) and improves glucose homeostasis and insulin sensitivity. Down-regulates lipogenic gene expression in hepatocytes. Exhibits anti-proliferative activity in osteosarcoma cells (IC50 = 800, 150, 330, and 170 nM in HOB-c, KHOS, KHOSR2, and U2OS cells, respectively). Enhances the effectiveness of chemotherapeutic agents by inducing intrinsic mitochondrial-dependent apoptotic pathway. Reported to interact with multi cellular targets, namely, Nrf2-Keap1, IKK, JAK-STAT, PPARγ, ErbB2, PTEN, mTOR and Arp3 and covalently modify active site Cys residue via Michael addition.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number218600-53-4
Chemical formulaC₃₂H₄₃NO₄
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml). Use only fresh DMSO for reconstitution.
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesLiby, K.T. and Sporn, M.B., 2012. Pharmacol. Rev. 64, 972.
Saha, P.K. et al. 2010. J. Biol. Chem. 285, 40581.
Ryu, K., et al. 2010. BMC Cancer 10, 187.
Liby, K.T., et al. 2007. Nat. Rev. Cancer 7, 357.
Shishodia S., et al. 2006. Clin. Cancer Res. 12, 1828.
Zou, W., et al. 2004. Cancer Res. 64, 7570.
Kim, Y., et al. 2002. J. Biol. Chem. 277, 22320.
Konopleva, M., et al. 2002. Blood 99, 326.
Wang, Y., et al. 2000. Mol Endocrinol. 14, 1550.