217505 Sigma-AldrichCBP-CREB Interaction Inhibitor - CAS 92-78-4 - Calbiochem
The CBP-CREB Interaction Inhibitor, also referenced under CAS 92-78-4, controls the biological activity of CBP-CREB.
More>> The CBP-CREB Interaction Inhibitor, also referenced under CAS 92-78-4, controls the biological activity of CBP-CREB. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Luciferase Inhibitor III, N-(4-Chlorophenyl)-3-hydroxy-2-naphthamide, KIX-KID Interaction Inhibitor
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 92-78-4 | C₁₇H₁₂ClNO₂ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 217505-250MG | Glass bottle | 250 mg |
| Description | |
|---|---|
| Overview | A cell-permeable naphthamide compound that effectively blocks the interaction between the KIX domain of CBP and the KID domain of CREB in HEK293T-based and cell-free Renilla luciferase (RLuc) complementation assays (IC50 = 2.26 and 2.9 µM, respectively) by directly binding to CBP's KIX domain (Kd ~8.6 µM using a recombinant KIX). Shown to inhibit CRE- (cAMP response element) dependent transcription activity induced by forskolin (Cat. No. 344270) in a HEK293T-based RLuc reporter assay (IC50 <2.5 µM), while exhibiting little effect against the KID-independent CREB-VP16 transcription activity. Also reported to inhibit the enzymatic activity of Firefly luciferase (IC50 ~1 µM), but not that of RLuc. |
| Catalogue Number | 217505 |
| Brand Family | Calbiochem® |
| Synonyms | Luciferase Inhibitor III, N-(4-Chlorophenyl)-3-hydroxy-2-naphthamide, KIX-KID Interaction Inhibitor |
| References | |
|---|---|
| References | Li, B.X. and Xiao, X., 2009. ChemBioChem 10, 2721. Best, J.L., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 17622. |
| Product Information | |
|---|---|
| CAS number | 92-78-4 |
| Form | Beige solid |
| Hill Formula | C₁₇H₁₂ClNO₂ |
| Chemical formula | C₁₇H₁₂ClNO₂ |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Purity | ≥97% by HPLC |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 217505-250MG | 04055977219371 |