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SCT073 BioTracker NIR Amyloid-ß Plaque Imaging Dye

Near-Infrared probe for live cell imaging of amyloid-ß (Aß) plaques, critical for the early detection of Alzheimer's disease.

SCT073
1 mg  
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
Catalogue NumberSCT073
DescriptionBioTracker NIR Amyloid-ß Plaque Imaging Dye
OverviewAlzheimer's disease (AD) is a progressive neurodegenerative brain disorder and does not have a proper cure yet. The formation and accumulation of amyloid-ß (Aß) plaques in the brain is thought to be a critical pathological hallmark for early diagnosis of AD. Current gold standard probes for histological staining of amyloid fibrils, such as thioflavin derivatives, have several drawbacks. These probes suffer from noises from always-on pattern, limited blood-brain-barrier (BBB) penetration and distorted signals.

BioTracker NIR Amyloid-ß Plaque Imaging Dye is aggregation-induced-emission (AIE) active probe that can be used to detect amyloid-ß plaques in vivo as well as ex-vivo. This probe has been tested in mouse models of AD, as well as ex-vivo brain tissue sections. The BioTracker probe possess excellent features, such as: (1) ultrahigh signal-to-noise (S/N) ratio with integrating background minimization and fidelity signal amplification, (2) remarkable binding affinity to Aß plaques with efficient BBB penetrability, and (3) NIR AIE-active emission with excellent photostability.

Spectral Properties
Absorbance: 500 nm
Emission: 720 nm

References
Fu W, et al. Rational Design of Near-Infrared Aggregation-Induced-Emission Active Probes: In Situ Mapping of Amyloid-ß Plaques with Ultrasensitivity and High-Fidelity. J. Am. Chem. Soc. 2019, 141, 3171-3177.
Alternate Names
  • Live Cell Imaging Probe
References
Product Information
Detection methodFluorescence
PresentationLyophilized. Dark red solid.
Applications
ApplicationNear-Infrared probe for live cell imaging of amyloid-ß (Aß) plaques, critical for the early detection of Alzheimer's disease.
Key Applications
  • Cell Based Assays
  • Immunocytochemistry
  • Immunohistochemistry
  • Neuroscience
Application NotesLive cell fluorescent imaging
Biological Information
Molecular Weight564.7
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssurancePurity ≥ 97% confirmed by HPLC, HNMR, LC-MS, and elemental analysis.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStore BioTracker NIR Amyloid-b Imaging Dye at -20 oC, dessicate and protect from light.
Note: Centrifuge vial briefly to collect conents at bottom of vial before opening.
Packaging Information
Material Size1 mg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
SCT073 04061842297535