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SCT067 BioTracker IRI-1 b-Amyloid Plaque Live Cell Dye

Live cell imaging probe for beta-amyloid plaques to study neurodegenrative diseases such as Alzheimer's disease.

SCT067
1 mg  
Purchase on Sigma-Aldrich

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Overview

Replacement Information

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Fluorescence at Near-Infrared range
Description
Catalogue NumberSCT067
DescriptionBioTracker IRI-1 b-Amyloid Plaque Live Cell Dye
OverviewAlzheimer’s disease (AD) is a common progressive
neurodegenerative disease eventually leading to fatality.
Significant accumulation of pathological proteinaceous deposits
in the brain, including Aβ plaques, are present decades before
symptoms can be perceived. As such, the delay between
pathological brain chemistry changes and symptoms creates a
window of opportunity for potential treatments.

BioTracker IRI-1 b-Amyloid plaque live cell dye is a near-infrared-emissive two-photon microscopy (TPM) dye with high affinity for Aß-fibrils. The dye demonstrates a ~167-fold increase in fluorescence in the presence of Aß-fibrils. SCT067 achieves this while maintaining large two-photon cross-section, a large signal to background ratio, high BBB permeability, and emission reaching into the near-infrared (NIR, > 650 nm). This dye has been used for ex-vivo and in vivo TPM imaging of Aß-fibrils in mouse brains.

Spectral Properties
For Two-photon microscopy.
Excitation: 850 nm
Emission: 580- 779 nm

References
Shin J et al. Harnessing Intramolecular Rotation to Enhance Two-Photon Imaging of Aß Plaques Through Minimizing Background fluorescence. Angew Chem Int Ed Engl. 2019 Apr 16;58(17):5648-5652.
Alternate Names
  • Live cell imaging probe
References
Product Information
Detection methodFluorescence
PresentationLyophilized
Applications
ApplicationLive cell imaging probe for beta-amyloid plaques to study neurodegenrative diseases such as Alzheimer's disease.
Key Applications
  • Cell Based Assays
  • Fluorescence
  • Neuroscience
Application NotesLive cell fluorescent imaging
Biological Information
Molecular Weight249.74 g/ml
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceStructure confirmed by HNMR. Elemental analysis consistent with structure.
Molar Mass: 249.74 g/mol
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStore BioTracker IRI-1 b-Amyloid Plaque Live Cell Dye at -20°C, desiccate and protect from light
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening.
Packaging Information
Material Size1 mg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
SCT067 04061841072775