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197330 Bcl-2 Inhibitor - CAS 383860-03-5 - Calbiochem

The Bcl-2 Inhibitor, also referenced under CAS 383860-03-5, controls the biological activity of Bcl-2. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2,9-Dimethoxy-11,12-dihydrodibenzo[c,g][1,2]-diazocine 5,6-dioxide (A) and 5,5ʹ-Dimethoxy-2,2ʹ-dinitrosobenzyl (B)

Primary Target: Bcl-2
197330
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
383860-03-5C₁₆H₁₆N₂O₄
Description
Overview

This product has been discontinued.



Contains mixture of two tautomers (A and B). A potent, cell-permeable, Bcl-2 inhibitor that competes with Bak BH3 peptide for binding to Bcl-2 and Bcl-xL in vitro (IC50 = 10 µM and 7 µM, respectively). Reduces cell viability and growth in the HL-60 cell line with high Bcl-2 expression (IC50 = 4 µM). Also induces apoptosis in a dose-dependent manner in cancer cells exhibiting high Bcl-2 expression with little effect on cancer cells with low Bcl-2 expression.
Catalogue Number197330
Brand Family Calbiochem®
Synonyms2,9-Dimethoxy-11,12-dihydrodibenzo[c,g][1,2]-diazocine 5,6-dioxide (A) and 5,5ʹ-Dimethoxy-2,2ʹ-dinitrosobenzyl (B)
References
ReferencesEnyedy, I.J., et al. 2001. J. Med. Chem. 44, 4313.
Product Information
CAS number383860-03-5
FormGreen solid
Hill FormulaC₁₆H₁₆N₂O₄
Chemical formulaC₁₆H₁₆N₂O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetBcl-2
Primary Target IC<sub>50</sub>10 µM and 7 µM for competing with Bak BH3 peptide for binding to Bcl-2 and Bcl-xL in vitro, respectively; 4 µM for reducing cell viability and growth in the HL-60 cell line with high Bcl-2 expression
Purity≥97% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze under inert gas (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
197330 0

Documentation

Bcl-2 Inhibitor - CAS 383860-03-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Bcl-2 Inhibitor - CAS 383860-03-5 - Calbiochem Certificates of Analysis

TitleLot Number
197330

References

Reference overview
Enyedy, I.J., et al. 2001. J. Med. Chem. 44, 4313.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-April-2011 RFH
Synonyms2,9-Dimethoxy-11,12-dihydrodibenzo[c,g][1,2]-diazocine 5,6-dioxide (A) and 5,5ʹ-Dimethoxy-2,2ʹ-dinitrosobenzyl (B)
DescriptionContains a mixture of two tautomers (A and B). Potent, cell-permeable Bcl-2 inhibitor that competes with Bak BH3 peptide for binding to Bcl-2 and Bcl-XL in vitro (IC50 = 10 µM and 7 µM, respectively). Shown to reduce cell viability (IC50 = 10 µM) and growth in HL60 cells with high levels of Bcl-2 expression (IC50 = 4 µM). Induces apoptosis in a dose-dependent manner in cancer cells expressing high levels of Bcl-2, but has little or no effect on cells that express low levels of Bcl-2.
FormGreen solid
Intert gas (Yes/No) Packaged under inert gas
CAS number383860-03-5
Chemical formulaC₁₆H₁₆N₂O₄
Structure formulaStructure formula
Purity≥97% by TLC
SolubilityDMSO (2.5 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze under inert gas (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesEnyedy, I.J., et al. 2001. J. Med. Chem. 44, 4313.