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203408 BLEOCIN™ Antibiotic, Streptomyces verticillus, Cell Culture-Tested - CAS 55658-47-4 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
203408
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
55658-47-4C₅₇H₈₉CuN₁₉O₂₁S₂ · 3HCl
Description
Overview

This product has been discontinued.



A unique antibiotic of the bleomycin family that is toxic to eukaryotic and prokaryotic cells. BLEOCIN™ Antibiotic cleaves double-stranded DNA and inhibits DNA synthesis, resulting in cell death. Can be used for selection of recombinant clones in a variety of cell types transfected with vectors containing a ble resistance marker. Copper content: ≥3.5%. Potency: ≥750 µg/mg.
Catalogue Number203408
Brand Family Calbiochem®
References
ReferencesSergeev, D.S., et al. 1995. Bioorg. Khim. 21, 695.
Mulsant, P., et al. 1988. Somatic Cell and Molecular Genetics 14, 243.
Ehrenfeld, G.M., et al. 1987. Biochemistry 26, 931.
Takita, T., et al. 1972. J. Antibiot. 25, 755.
Product Information
CAS number55658-47-4
FormBlue lyophilized solid
Hill FormulaC₅₇H₈₉CuN₁₉O₂₁S₂ · 3HCl
Chemical formulaC₅₇H₈₉CuN₁₉O₂₁S₂ · 3HCl
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥85% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSEC5990700
Safety Information
R PhraseR: 20/21/22-36/37/38-40-42/43

Harmful by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
Limited evidence of a carcinogenic effect.
May cause sensitization by inhalation and skin contact.
S PhraseS: 22-26-36/37/39-45

Do not breathe dust.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful & Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
203408 0

Documentation

BLEOCIN™ Antibiotic, Streptomyces verticillus, Cell Culture-Tested - CAS 55658-47-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

BLEOCIN™ Antibiotic, Streptomyces verticillus, Cell Culture-Tested - CAS 55658-47-4 - Calbiochem Certificates of Analysis

TitleLot Number
203408

References

Reference overview
Sergeev, D.S., et al. 1995. Bioorg. Khim. 21, 695.
Mulsant, P., et al. 1988. Somatic Cell and Molecular Genetics 14, 243.
Ehrenfeld, G.M., et al. 1987. Biochemistry 26, 931.
Takita, T., et al. 1972. J. Antibiot. 25, 755.

Brochure

Title
Antibiotics Profiler
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-September-2007 RFH
DescriptionA unique antibiotic of the bleomycin family that is toxic to eukaryotic and prokaryotic cells. BLEOCIN™ cleaves double-stranded DNA and inhibits DNA synthesis, resulting in cell death. Can be used for selection of recombinant clones in a variety of cell types transfected with vectors containing a ble resistance marker. Copper content: ≥3.5%. Potency: ≥750 µg/mg.
FormBlue lyophilized solid
CAS number55658-47-4
RTECSEC5990700
Chemical formulaC₅₇H₈₉CuN₁₉O₂₁S₂ · 3HCl
Structure formulaStructure formula
Purity≥85% by HPLC
SolubilityH₂O (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
Toxicity Harmful & Carcinogenic / Teratogenic
ReferencesSergeev, D.S., et al. 1995. Bioorg. Khim. 21, 695.
Mulsant, P., et al. 1988. Somatic Cell and Molecular Genetics 14, 243.
Ehrenfeld, G.M., et al. 1987. Biochemistry 26, 931.
Takita, T., et al. 1972. J. Antibiot. 25, 755.