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14-512M Axl Protein, active, 250 µg

Active, N-terminal His6-tagged, recombinant amino acids 473-end human Axl, for use in Kinase Assays.

Axl Protein, active, 250 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
14-512M
250 µg  Also available in 10 μg size (cat#14-512) and in bulk (cat# 14-512-K).
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
Catalogue Number14-512M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionAxl Protein, active, 250 µg
OverviewN-terminal His6-tagged, recombinant amino acids 473-end human Axl
References
Product Information
Quality LevelMQ100
Applications
ApplicationActive, N-terminal His6-tagged, recombinant amino acids 473-end human Axl, for use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Sourceexpressed in Sf21 cells
Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene SummaryThe protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gene Symbol
  • AXL
  • UFO
Protein TargetAxl
Purification MethodNi2+/NTA-agarose
Target Sub-FamilyTK
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P30530 # May function as a signal transducer between specific cell types of mesodermal origin.
SIZE: 887 amino acids; 97437 Da
SUBUNIT: Heterodimer and heterotetramer with GAS6.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
DISEASE:SwissProt: P30530 # Has transforming potential in patients with chronic myeloproliferative disorder or chronic myelocytic leukemia.
SIMILARITY: SwissProt: P30530 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily. & Contains 2 fibronectin type-III domains. & Contains 2 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
Molecular Weight48kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assuranceroutinely evaluated by phosphorylation of Axl-tide
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C
Packaging Information
Material Size250 µg
Material PackageAlso available in 10 μg size (cat#14-512) and in bulk (cat# 14-512-K).
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
14-512M 04053252675041

Related Products & Applications

Alternative Packsize

Catalogue Number Description
14-512 Axl Protein, active, 10 µg

Product Families

Kinase & Phosphatase Products

Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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Categories

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases