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189401 Aurothiomalate

A gold(I) compound that inhibits the activity of IKK and disrupts PB1 domain-mediated interactions between Par6 and PKCι.

Aurothiomalate MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Aurothiomalate, Sodium Salt, AuTM, ATM

189401
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
12244-57-4C₄H₄AuNaO₄S
Description
Overview

This product has been discontinued.




A gold(I) compound that inhibits the activity of IKK (ID50 = 10.9 µM) and disrupts PB1 (Phox and Bem1p) domain-mediated interactions between Par6 and PKCι (IC50 = ~ 1 µM) by modifying cysteine residues within the catalytic domain of IKK and the PB1 domain of PKCι. Inhibits PKCι-dependent Rac1 activation in A549 cells.
Catalogue Number189401
Brand Family Calbiochem®
SynonymsAurothiomalate, Sodium Salt, AuTM, ATM
References
ReferencesErdogan, E., et al. 2006. J. Biol. Chem. 281, 28450.
Stallings-Mann, M., et al. 2006. Cancer Res. 66, 1767.
Jeon, K.I., et al. 2000. J. Immunol. 164, 5981.
Handel, M.L., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 4497.
Product Information
CAS number12244-57-4
FormOff-white solid
Hill FormulaC₄H₄AuNaO₄S
Chemical formulaC₄H₄AuNaO₄S
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥98% (Gold content)
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
189401 0

Documentation

Aurothiomalate Certificates of Analysis

TitleLot Number
189401

References

Reference overview
Erdogan, E., et al. 2006. J. Biol. Chem. 281, 28450.
Stallings-Mann, M., et al. 2006. Cancer Res. 66, 1767.
Jeon, K.I., et al. 2000. J. Immunol. 164, 5981.
Handel, M.L., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 4497.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-April-2008 RFH
SynonymsAurothiomalate, Sodium Salt, AuTM, ATM
DescriptionA gold(I) compound that blocks NF-κB activation and PKCι-dependent Rac1 signaling and displays antitumor properties. Modifies metal sensitive cysteine residues of IKK and PKCι, and inhibits the activity of IKK (ID50 = 10.9 µM) and disrupts PB1 (Phox and Bem1p) domain-mediated interactions between Par6 and PKCι (IC50 ~ 1 µM).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number12244-57-4
Chemical formulaC₄H₄AuNaO₄S
Structure formulaStructure formula
Purity≥98% (Gold content)
SolubilityH₂O (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
Merck USA index14, 4518
ReferencesErdogan, E., et al. 2006. J. Biol. Chem. 281, 28450.
Stallings-Mann, M., et al. 2006. Cancer Res. 66, 1767.
Jeon, K.I., et al. 2000. J. Immunol. 164, 5981.
Handel, M.L., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 4497.