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189404 Aurora Kinase Inhibitor II - CAS 331770-21-9 - Calbiochem

The Aurora Kinase Inhibitor II, also referenced under CAS 331770-21-9, controls the biological activity of Aurora Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(4ʹ-Benzamidoanilino)-6,7-dimethoxyquinazoline, Aurora Kinase Inhibitor II

Primary Target: Aurora Kinase
189404
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
331770-21-9C₂₃H₂₀N₄O₃
Description
OverviewA cell-permeable anilinoquinazoline compound that acts as a potent, selective, and ATP-competitive inhibitor of Aurora kinases (IC50 = 310 nM and 240 nM for Aurora A and B, respectively, 1.25 µM in MCF7 cells). Due to its limited aqueous solubility and high serum binding property, it is recommended for in vitro, but not in vivo, use.
Catalogue Number189404
Brand Family Calbiochem®
Synonyms4-(4ʹ-Benzamidoanilino)-6,7-dimethoxyquinazoline, Aurora Kinase Inhibitor II
References
ReferencesHeron, N.M., et al. 2006. Bioorg. Med. Chem. Lett. 16, 1320.
Mortlock, A.A., et al. 2005. Curr. Top. Med. Chem. 5, 807.
Product Information
CAS number331770-21-9
ATP CompetitiveY
FormYellow solid
Hill FormulaC₂₃H₂₀N₄O₃
Chemical formulaC₂₃H₂₀N₄O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetAurora Kinase
Primary Target IC<sub>50</sub>310 nM and 240 nM for Aurora A and B, respectively, 1.25 µM in MCF7 cells
Purity≥90% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
189404 0

Documentation

Aurora Kinase Inhibitor II - CAS 331770-21-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Aurora Kinase Inhibitor II - CAS 331770-21-9 - Calbiochem Certificates of Analysis

TitleLot Number
189404

References

Reference overview
Heron, N.M., et al. 2006. Bioorg. Med. Chem. Lett. 16, 1320.
Mortlock, A.A., et al. 2005. Curr. Top. Med. Chem. 5, 807.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-August-2007 JSW
Synonyms4-(4ʹ-Benzamidoanilino)-6,7-dimethoxyquinazoline, Aurora Kinase Inhibitor II
DescriptionA cell-permeable, potent, selective, and ATP-competitive inhibitor of Aurora kinases (IC50 = 310 nM and 240 nM for Aurora A and B, respectively, 1.25 µM in MCF7 cells). Due to its limited aqueous solubility and high serum binding property, it is recommended for in vitro, but not in vivo, use.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number331770-21-9
Chemical formulaC₂₃H₂₀N₄O₃
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesHeron, N.M., et al. 2006. Bioorg. Med. Chem. Lett. 16, 1320.
Mortlock, A.A., et al. 2005. Curr. Top. Med. Chem. 5, 807.