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182800 Ascomycin, Streptomyces hygroscopicus - CAS 11011-38-4 - Calbiochem

An ethyl analog of FK506 with similar immunosuppressant properties.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Immunomycin, FR-900520

Primary Target: Immunophilins
182800
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
11011-38-4C₄₃H₆₉NO₁₂
Description
OverviewAn ethyl analog of FK506 with similar immunosuppressant properties. Acts by binding to immunophilins. Inhibits the synthesis of Th-1 and Th-2 type cytokines in target cells.
Catalogue Number182800
Brand Family Calbiochem®
SynonymsImmunomycin, FR-900520
References
ReferencesPaul, C., et al. 2000. Expert Opin. Invest. Drugs 9, 69.
Kawai, M., et al. 1993. FEBS Lett. 316, 107.
Pilot-Matias, T.J., et al. 1993. Gene 128, 219.
Shafiee, A., et al. 1993. J. Antibiot. 46, 1397.
Petros, A.M., et al. 1992. J. Med. Chem. 35, 2467.
Product Information
CAS number11011-38-4
ATP CompetitiveN
FormWhite crystalline solid
Hill FormulaC₄₃H₆₉NO₁₂
Chemical formulaC₄₃H₆₉NO₁₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Biological activityFully active via yeast rotamase (FK 506 binding protein) inhibition
Primary TargetImmunophilins
Purity≥90% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSCI7570000
Safety Information
R PhraseR: 20/21/22-36/37/38

Harmful by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 3 days at -20°C. Anhydrous DMSO stock solutions are stable for up to 1 month -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
182800 0

Documentation

Ascomycin, Streptomyces hygroscopicus - CAS 11011-38-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Ascomycin, Streptomyces hygroscopicus - CAS 11011-38-4 - Calbiochem Certificates of Analysis

TitleLot Number
182800

References

Reference overview
Paul, C., et al. 2000. Expert Opin. Invest. Drugs 9, 69.
Kawai, M., et al. 1993. FEBS Lett. 316, 107.
Pilot-Matias, T.J., et al. 1993. Gene 128, 219.
Shafiee, A., et al. 1993. J. Antibiot. 46, 1397.
Petros, A.M., et al. 1992. J. Med. Chem. 35, 2467.

Citations

Title
  • Brian Adams, et al. (2005) A novel class of dual-family immunophilins. Journal of Biological Chemistry 280, 24308-24314.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision17-April-2008 RFH
    SynonymsImmunomycin, FR-900520
    DescriptionEthyl analog of FK-506 that possesses the same potent immunosuppressive properties as the parent compound. Inhibition of the Ca2+/calmodulin activated phosphatase calcineurin (IC50 = 10 nM) by the ascomycin/FK-506 binding protein complex is believed to be important in the mechanism of immunosuppression. Acts by binding immumophilins.
    FormWhite crystalline solid
    CAS number11011-38-4
    RTECSCI7570000
    Chemical formulaC₄₃H₆₉NO₁₂
    Structure formulaStructure formula
    Purity≥90% by HPLC
    Biological activityFully active via yeast rotamase (FK 506 binding protein) inhibition
    SolubilityDMSO (1 mg/ml) or Ethanol (1 mg/ml)
    Storage -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 3 days at -20°C. Anhydrous DMSO stock solutions are stable for up to 1 month -20°C.
    Toxicity Harmful
    ReferencesPaul, C., et al. 2000. Expert Opin. Invest. Drugs 9, 69.
    Kawai, M., et al. 1993. FEBS Lett. 316, 107.
    Pilot-Matias, T.J., et al. 1993. Gene 128, 219.
    Shafiee, A., et al. 1993. J. Antibiot. 46, 1397.
    Petros, A.M., et al. 1992. J. Med. Chem. 35, 2467.
    Citation
  • Brian Adams, et al. (2005) A novel class of dual-family immunophilins. Journal of Biological Chemistry 280, 24308-24314.
    		•