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06-913 Anti-Sin3A Antibody

06-913
200 µg  
Purchase on Sigma-Aldrich

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Overview

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, MWBRbPurifiedPolyclonal Antibody
Description
Catalogue Number06-913
Brand Family Upstate
Trade Name
  • Upstate
DescriptionAnti-Sin3A Antibody
Product Information
FormatPurified
Presentation0.07M Tris-glycine, pH 7.2, 0.105M NaCl, 0.035% sodium azide containing 30% glycerol
Applications
ApplicationDetect Sin3A with Anti-Sin3A Antibody (Rabbit Polyclonal Antibody), that has been shown to work in WB.
Key Applications
  • Western Blotting
Biological Information
Immunogenpeptide (KRRLDDQESPVYAAQQRR-C) corresponding to amino acids 2-18 of mouse mSin3A
HostRabbit
SpecificitySin3A
IsotypeIgG
Species Reactivity
  • Human
  • Mouse
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThe protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex.
Gene Symbol
  • SIN3A
  • KIAA0700
  • FLJ90319
  • DKFZP434K2235
Purification MethodProtein A chromatography
UniProt Number
UniProt SummaryFUNCTION: SwissProt: Q96ST3 # Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3A to DNA. Acts as a corepressor for REST (By similarity).
SIZE: 1273 amino acids; 145175 Da
SUBUNIT: Interacts with MBD2, SAP30, NCOR1 and SDS3 (By similarity). Interacts with MXI1, MAD, DACH1, HCFC1, SETDB1 and SFPQ. Interacts with PHF12 in a complex composed of HDAC1, PHF12 and SAP30. Interacts with MAD3 and MAD4. Interacts with REST (By similarity). Interacts with BRMS1L, SAP130, SUDS3/SAP45, ARID4B/SAP180 and HDAC2. Interacts with SAP30L.
SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus. Note=Recruited to the nucleolus by SAP30L.
SIMILARITY: SwissProt: Q96ST3 ## Contains 3 PAH (paired amphipathic helix) repeats.
Molecular Weight150kDa
Product Usage Statements
Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates from Hela nuclear extract
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions2 years at -20°C
Packaging Information
Material Size200 µg
Global Trade Item Number
Catalogue Number GTIN
06-913 04053252728938