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MABF949 Anti-Rabies Virus Antibody, clone 1112-1

Anti-Rabies Virus, clone 1112-1, Cat. No. MABF949, is a mouse monoclonal antibody that detects glycoprotein of strain ERA rabbies virus. It has been tested for use in Flow Cytometry and for Neutralizing.

Anti-Rabies Virus Antibody, clone 1112-1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology UniProt Number: P03524
MABF949
100 μg  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
A Broad Range Of SpeciesFC, NEUTMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABF949
DescriptionAnti-Rabies Virus Antibody, clone 1112-1
Background InformationGlycoprotein of Evelyn Rokitniki Abelseth (ERA) SAD derived Rabies virus strain (UniProt: P03524) is encoded by the G gene. It belongs to the lyssavirus glycoprotein of the Rhabdoviridae family. This glycoprotein is a single pass type I virion membrane protein that helps in attaching the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. It has been shown that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (N-CAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and facilitate rabies virus entry into cells. Arg352 of Glycoprotein is highly involved in rabies virus pathogenicity and mutation at this site dramatically attenuates the virus.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal antibody IgG1 in PBS without azide.
Quality LevelMQ100
Applications
ApplicationAnti-Rabies Virus, clone 1112-1, Cat. No. MABF949, is a mouse monoclonal antibody that detects glycoprotein of strain ERA rabbies virus. It has been tested for use in Flow Cytometry and for Neutralizing.
Key Applications
  • Flow Cytometry
  • Neutralizing
Application NotesNeutralizing Analysis: A representative lot neutralized Rabies Virus (Bunschoten, H., et. al. (1989). J Gen Virol. 70 ( Pt 2):291-8; Dietzchold, B., et. al. (1992). Proc Natl Acad Sci USA. 89(15):7252-6; Muller, T., et. al. (2009). PLoS Neql Trop Dis. 3(11):e542; Schumacher, C.L., et. al. (1989). J Clin Invest. 84(3):971-5).
Biological Information
ImmunogenGlycoprotein of ERA (Evelyn Rokitniki Abelseth) strain Rabies virus.
Clone1112-1
ConcentrationPlease refer to lot specific datasheet.
HostMouse
SpecificityClone 1112-1 detects glycoprotein of ERA strain of rabies virus in L929 cells that express rabies protein.
IsotypeIgG1κ
Species Reactivity
  • A Broad Range Of Species
Species Reactivity NoteRabies Virus.
Antibody TypeMonoclonal Antibody
Purification MethodProtein G purified
UniProt Number
Molecular Weight58.66 kDa calculated.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Flow Cytometry in L929 expressing rabies protein.

Flow Cytometry Analysis: 1 µg of this antibody detected Rabies Virus in one million L929 cells expressing rabies protein.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABF949 04054839224317

Documentation

Anti-Rabies Virus Antibody, clone 1112-1 Certificates of Analysis

TitleLot Number
Anti-Rabies Virus, Serum Free, clone 1112-1 Monoclonal Antibody 3067369
Anti-Rabies Virus, Serum Free, clone 1112-1 Monoclonal Antibody Q3067368
Anti-Rabies Virus, clone 1112-1 - 3194618 3194618
Anti-Rabies Virus, clone 1112-1 - 3397931 3397931
Anti-Rabies Virus, clone 1112-1 - 3442504 3442504
Anti-Rabies Virus, clone 1112-1 - 3533075 3533075
Anti-Rabies Virus, clone 1112-1 - 3689453 3689453
Anti-Rabies Virus, clone 1112-1 - 3734493 3734493
Anti-Rabies Virus, clone 1112-1 - 3737956 3737956
Anti-Rabies Virus, clone 1112-1 - 3789991 3789991
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