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423500 Anti-Klotho Rabbit pAb

This Anti-Klotho Rabbit pAb is validated for use in ELISA, Immunoblotting for the detection of Klotho.

Anti-Klotho Rabbit pAb MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Anti-KL

423500
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Species ReactivityHostAntibody Type
MRbPolyclonal Antibody

Products

Catalogue NumberPackaging Qty/Pack
423500-50UG Glass bottle 50 μg
Description
OverviewRecognizes the ~100 kDa Klotho protein.
Catalogue Number423500
Brand Family Calbiochem®
SynonymsAnti-KL
References
ReferencesKuro-o, M., et al. 1997. Nature 390, 45.
Martin, G.M. and Mian, I.S. 1997. Nature 390, 18.
Product Information
FormLiquid
FormulationIn PBS, 0.1% BSA, pH 7.5.
PreservativeNone
Quality LevelMQ100
Applications
Key Applications Enzyme-Linked Immunosorbent Assay
Immunoblotting (Western Blotting)
Application NotesELISA (1:10,000-1:100,000)
Immunoblotting (1-10 µg/ml, chemiluminescence)
Application CommentsVariables associated with assay conditions will dictate the optimal working dilution.
Biological Information
Immunogena synthetic peptide corresponding to a 17-amino acid sequence near the C-terminus of murine Klotho
ImmunogenMouse
HostRabbit
IsotypeIgG
Species Reactivity
  • Mouse
Antibody TypePolyclonal Antibody
Concentration Label Please refer to vial label for lot-specific concentration
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage -20°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
423500-50UG 04055977187304

Documentation

Anti-Klotho Rabbit pAb SDS

Title

Safety Data Sheet (SDS) 

Anti-Klotho Rabbit pAb Certificates of Analysis

TitleLot Number
423500

References

Reference overview
Kuro-o, M., et al. 1997. Nature 390, 45.
Martin, G.M. and Mian, I.S. 1997. Nature 390, 18.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-October-2009 RFH
SynonymsAnti-KL
ApplicationELISA (1:10,000-1:100,000)
Immunoblotting (1-10 µg/ml, chemiluminescence)
DescriptionImmunoaffinity purified rabbit polyclonal antibody. Recognizes the ~100 kDa Klotho protein.
BackgroundInactivation mutation of the recently discovered klotho gene in mice causes a syndrome resembling aging. Homozygous mutant klotho (kl/kl) mice exhibit premature aging phenotypes such as osteoporosis, age related skin changes, ectopic calcification, atrophy of genital organs and thymus, atherosclerosis, emphysema, ataxia, and short life span. The kl gene encodes a membrane protein whose extracellular domain carries homology to β-glucosidases. There also exists a splice variant of kl mRNA that encodes a putative secreted protein in both human and mouse. kl gene expression was observed to be tissue specific. Improvement of systemic aging phenotypes in kl/kl mice occurs even when the exogenous expression was limited to some organs, suggesting that KL associated aging is regulated through a humoral signaling pathway.
HostRabbit
Immunogen speciesMouse
Immunogena synthetic peptide corresponding to a 17-amino acid sequence near the C-terminus of murine Klotho
IsotypeIgG
Speciesmouse
FormLiquid
FormulationIn PBS, 0.1% BSA, pH 7.5.
Concentration Label Please refer to vial label for lot-specific concentration
PreservativeNone
CommentsVariables associated with assay conditions will dictate the optimal working dilution.
Storage Avoid freeze/thaw
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Standard Handling
ReferencesKuro-o, M., et al. 1997. Nature 390, 45.
Martin, G.M. and Mian, I.S. 1997. Nature 390, 18.