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MABC971 Anti-Kallikrein-13/KLK13 Antibody, clone 33.1

This Anti-Kallikrein-13/KLK13 Antibody, clone 33.1 is validated for use in Immunohistochemistry and ELISA for the detection of Kallikrein-13/KLK13.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Tumor Markers Gene Symbol: KLK13, KLKL4 UniProt Number: Q9UKR3
MABC971
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HIHC, ELISAMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABC971
DescriptionAnti-Kallikrein-13/KLK13 Antibody, clone 33.1
Alternate Names
  • Kallikrein-13
  • Kallikrein-like protein 4
  • KLK-L4
Background InformationKallikreins-related peptidases (KLKs) are proteases that are important for the desquamation process of the skin (cell shedding). Kallikreins are also associated with carcinogenesis and some serve as a novel cancer and other disease biomarkers. Kallikrein-13/KLK13 is important in lung cancer by allowing lung adenocarcinoma spreading through promoting the expression of various adhesion molecules and it in assisting in extracellular matrix protein degradation necessary for movement. Kallikrein-13/KLK13 also plays a role in salivary tumors and ovarian cancer as well as other cancers in a similar fashion. In both normal and cancerous tissues, Kallikrein-13/KLK13 is secreted into the ECM and expressed in many tissues in both the embryo and adult.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgG1k in 0.1 M Sodium Bicarbonate buffer pH8.2 without preservatives.
Quality LevelMQ100
Applications
ApplicationThis Anti-Kallikrein-13/KLK13 Antibody, clone 33.1 is validated for use in Immunohistochemistry and ELISA for the detection of Kallikrein-13/KLK13.
Key Applications
  • Immunohistochemistry
  • ELISA
Application NotesImmunohistochemistry Analysis: A representative lot of this antibody detected Kallikrein-13/KLK13 in Normal ovarian surface epithelium and epithelial ovarian cancer tissues (White et al., (2009) British Journal of Cancer. 101:1107-1113).

ELISA: A representative lot of this antibody detected various Kallikrein-13/KLK13 concentrations of several human tissues (Kapadia et al., (2003) Clinical chemistry. 49(1):77–86).
Biological Information
ImmunogenRecombinant protein corresponding to Human Kallikrein-13/KLK13.
Clone33.1
ConcentrationPlease refer to lot specific datasheet.
HostMouse
IsotypeIgG1κ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • KLK13
  • KLKL4
Purification MethodProtein G Purified
UniProt Number
Molecular Weight30 kDa calculated
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Immunohistochemistry in human lung and human prostate tissue.

Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected Kallikrein-13/KLK13 in human prostate tissue.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABC971 04055977052985

Documentation

Anti-Kallikrein-13/KLK13 Antibody, clone 33.1 SDS

Title

Safety Data Sheet (SDS) 

Anti-Kallikrein-13/KLK13 Antibody, clone 33.1 Certificates of Analysis

TitleLot Number
Anti-Kallikrein-13/KLK13, clone 33.1 - Q2464790 Q2464790

References

Reference overviewPub Med ID
KLK6 and KLK13 predict tumor recurrence in epithelial ovarian carcinoma.
White, N M A, et al.
Br. J. Cancer, 101: 1107-13 (2009)  2009

Show Abstract 		19707197 19707197
Human kallikrein 13: production and purification of recombinant protein and monoclonal and polyclonal antibodies, and development of a sensitive and specific immunofluorometric assay.
Kapadia, Carl, et al.
Clin. Chem., 49: 77-86 (2003)  2003

Show Abstract 		12507963 12507963