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AB15014 Anti-Glycine Receptor α3 subunit Antibody

Anti-Glycine Receptor α3 subunit Antibody detects level of Glycine Receptor α3 subunit & has been published & validated for use in IH & WB.

Anti-Glycine Receptor α3 subunit Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurotransmitters & Receptors Gene Symbol: GLRA3 UniProt Number: O75311
AB15014
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, MIHC, WBRbPurifiedPolyclonal Antibody
Description
Catalogue NumberAB15014
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Glycine Receptor α3 subunit Antibody
Alternate Names
  • glycine receptor alpha 3 subunit
  • glycine receptor, alpha 3
  • glycine receptor
  • alpha-3 polypeptide, ligand gated ion channel
Background InformationGlycine receptor α3 subunit, also known as GLRA3, belongs to the ligand-gated ion channel family. Glycine functions as a inhibitory neurotransmitter throughout the CNS of mammals. The Glycine receptor is a neurotransmitter ligand-gated ion channel. GLRA3 is a pentamer that is composed of ligand binding alpha and structural beta subunits. When glycine binds to the receptor, chloride conductance increases which produces hyperpolarization. It is expressed in the hippocampus, olfactory bulb, and cerebellum. GLRA3 may be involved in human and murine neurological disorders.
References
Product Information
FormatPurified
Control
  • Fetal human brain tissue lysate
PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-Glycine Receptor α3 subunit Antibody detects level of Glycine Receptor α3 subunit & has been published & validated for use in IH & WB.
Key Applications
  • Immunohistochemistry
  • Western Blotting
Application NotesImmunohistochemistry Analysis: 1:100-500 dilution from a previous lot detected Glycine Receptor α3 subunit in mouse spinal cord and mouse eye tissue.
Biological Information
ImmunogenThis antibody is generated from rabbits immunized with a KLH conjugated linear peptide selected from residues surrounding the C-terminus of human Glycine Receptor α3 subunit.
EpitopeC-terminus
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityThis antibody recognizes Glycine Receptor α3 subunit.
Species Reactivity
  • Human
  • Mouse
Species Reactivity NoteDemonstrated to react with human and mouse. Rat (92%) homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • GLRA3
Purification MethodAffinity Purfied
UniProt Number
UniProt SummaryFUNCTION: SwissProt: O75311 # The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).
SIZE: 464 amino acids; 53800 Da
SUBUNIT: Pentamer composed of alpha and beta subunits (By similarity).
SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Widely distributed throughout the central nervous system.
DOMAIN: SwissProt: O75311 The N-terminal domain carries structural determinants essential for agonist and antagonist binding. TM2 is thought to form the innert wall of the chloride channel. The cytoplasmic loop is an important determinant of channel inactivation kinetics.
SIMILARITY: Belongs to the ligand-gated ionic channel (TC 1.A.9) family.
MISCELLANEOUS: The alpha subunit binds strychnine.
Molecular WeightApprox. 48 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain refrigerated at 2-8°C for up to 12 months.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
AB15014 04053252676062

Documentation

Anti-Glycine Receptor α3 subunit Antibody SDS

Title

Safety Data Sheet (SDS) 

Anti-Glycine Receptor α3 subunit Antibody Certificates of Analysis

TitleLot Number
Anti-Glycine Receptor #945;3 subunit - 1987458 1987458
Anti-Glycine Receptor 3 subunit -
Anti-Glycine Receptor 3 subunit - 2020860 2020860
Anti-Glycine Receptor 3 subunit - NRG1635488 NRG1635488
Anti-Glycine Receptor a3 subunit - 2274270 2274270
Anti-Glycine Receptor a3 subunit Polyclonal Antibody 2901551
Anti-Glycine Receptor alpha3 subunit - LV1816408 LV1816408
Anti-Glycine Receptor α3 subunit 3170243
Anti-Glycine Receptor α3 subunit - 2491204 2491204
Anti-Glycine Receptor α3 subunit - 3698133 3698133
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