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CBL242 Anti-Glucose Transporter GLUT-1 Antibody, CT

CBL242
100 µg  
Purchase on Sigma-Aldrich

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Overview

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, M, RIP, WBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberCBL242
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Glucose Transporter GLUT-1 Antibody, CT
Product Information
FormatAffinity Purified
Control
  • Colorectal carcinoma
PresentationThe polyclonal is presented in phosphate buffered saline containing 10mM sodium azide. We recommend that each laboratory determine an optimum working titre for use in its particular application.
Quality LevelMQ100
Applications
ApplicationAnti-Glucose Transporter GLUT-1 Antibody, C-terminus detects level of Glucose Transporter GLUT-1 & has been published & validated for use in IP & WB.
Key Applications
  • Immunoprecipitation
  • Western Blotting
Application NotesWestern blot analysis of GLUT-1 activity in adipose and muscle tissue (5μg/ml)

Immunoprecipitation of GLUT-1 (5μg/ml)

Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen12 amino acid peptide of the C-terminus of hGLUT-1 {LFHPLGADSQV} conjugated to KLH
EpitopeC-terminus
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificitySpecific for human glucose transporter 1 from muscle and adipose tissue. Does not cross-react with GLUT-4. The molecular weight of the glucose transporter precipitated by the serum is approximately 46 kDa.
Species Reactivity
  • Human
  • Mouse
  • Rat
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryGlucose transporters are integral membrane glycoproteins involved in transporting glucose into most cells. GLUT1 is a major glucose transporter in the mammalian blood-brain barrier. It is present at high levels in primate erythrocytes and brain endothelial cells.[supplied by OMIM]
Gene Symbol
  • SLC2A1
  • GLUT-1
  • MGC141896
  • GLUT1
  • MGC141895
  • GLUT
Purification MethodImmunoAffinity Purified
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P11166 # Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses.
SIZE: 492 amino acids; 54084 Da
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). Melanosome. Note=Localizes primarily at the cell surface (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
TISSUE SPECIFICITY: Expressed at variable levels in many human tissues.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
DISEASE: SwissProt: P11166 # Defects in SLC2A1 are the cause of autosomal dominant GLUT1 deficiency syndrome [MIM:606777]. This disease causes a defect in glucose transport across the blood-brain barrier. It is characterized by infantile seizures, delayed development, and acquired microcephaly.
SIMILARITY: SwissProt: P11166 ## Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Molecular Weight46 kDa
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsFor use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C for up to one year.
Packaging Information
Material Size100 µg
Global Trade Item Number
Catalogue Number GTIN
CBL242 04053252368295