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MABN1564-100UG Anti-DYRK1A Antibody, clone 11D9.1

Anti-DYRK1A, clone 11D9.1, Cat. No. MABN1564, is a highly specific mouse monoclonal antibody that targets DYRK1A and has been tested in Western Blotting.

Anti-DYRK1A Antibody, clone 11D9.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Gene Symbol: DYRK1A, DYRK, MNB, MNBH UniProt Number: Q13627
MABN1564-100UG
100 μg  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWBMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABN1564-100UG
DescriptionAnti-DYRK1A Antibody, clone 11D9.1
Alternate Names
  • Dual specificity tyrosine-phosphorylation-regulated kinase 1A
  • EC 2.7.12.1
  • Dual specificity YAK1-related kinase
  • HP86
  • Protein kinase minibrain homolog
  • MNBH
  • hMNB
Background InformationDual specificity tyrosine-phosphorylation-regulated kinase 1A (UniProt: Q13627; also known as EC 2.7.12.1, Dual specificity YAK1-related kinase, DYRK1A, HP86, Protein kinase minibrain homolog, MNBH, hMNB) is encoded by the DYRK1A (also known as DYRK, MNB, MNBH) gene (Gene ID: 1859) in human. DYRK1A is a dual-specificity kinase that possesses both serine/threonine and tyrosine kinase activities and plays a role in a signaling pathway regulating nuclear functions of cell proliferation. DYRK family members share a conserved kinase domain and an adjacent DYRK-homology domain or DH-box (DDDNXDY), while differing in their N- and C-terminal regions. DYRK1A is ubiquitous in its distribution and highest levels are observed in skeletal muscle, testis, fetal lung, and fetal kidney. It is also expressed in the developing central nervous system. DYRK1A is regulated by autophosphorylation on serine, threonine, and tyrosine residues, but catalyzes phosphorylation of a broad-range of substrates only on serine/threonine residues within the RPX(S/T)P motif with a preference for proline at position P+1 and arginine at position P-3. The ATP binding region of DYRK1A is localized to amino acids 165-173 and 238-241. Its protein kinase domain is localized to amino acids 159-479. Five isoforms of DYRK1A have been described that are produced by alternative splicing. Mutations in DYRK1A gene are known to cause autosomal dominant mental retardation that is characterized by primary microcephaly, severe mental retardation without speech, and anxious autistic behavior.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
ApplicationAnti-DYRK1A, clone 11D9.1, Cat. No. MABN1564, is a highly specific mouse monoclonal antibody that targets DYRK1A and has been tested in Western Blotting.
Key Applications
  • Western Blotting
Biological Information
ImmunogenGST/His-tagged recombinant fragment corresponding to the first 95 amino acids from human Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A).
Clone11D9.1
ConcentrationPlease refer to lot specific datasheet.
HostMouse
SpecificityClone 11D9.1 specifically detects human Dual specificity tyrosine-phosphorylation-regulated kinase 1A. It targets an epitope within the first 95 amino acids in the N-terminal region.
IsotypeIgG2bκ
Species Reactivity
  • Human
Species Reactivity NoteHuman.
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • DYRK1A
  • DYRK
  • MNB
  • MNBH
Purification MethodProtein G purified
UniProt Number
Molecular Weight~86 kDa observed; 85.58 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in human cerebral cortex tissue lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected DYRK1A in human cerebral cortex tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABN1564-100UG 04054839510281