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07-259 Anti-δ-Catenin Antibody

07-259
100 µg  
Purchase on Sigma-Aldrich

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Overview

Replacement Information

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
M, RWBRbPurifiedPolyclonal Antibody
Description
Catalogue Number07-259
Brand Family Upstate
Trade Name
  • Upstate
DescriptionAnti-δ-Catenin Antibody
Alternate Names
  • Catenin delta-2
  • Delta-catenin
  • Neural plakophilin-related ARM-repeat protein
  • Neurojungin
  • NPRAP
References
Product Information
FormatPurified
Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Applications
ApplicationAnti-δ-Catenin Antibody detects level of δ-Catenin & has been published & validated for use in WB. This Catenin delta-2 antibody has been validated for use in Mouse and Rat.
Key Applications
  • Western Blotting
Biological Information
ImmunogenGST fusion protein corresponding to residues 1-461 of mouse delta Catenin
EpitopeA.a. 1-461
HostRabbit
Specificitydelta Catenin
IsotypeIgG
Species Reactivity
  • Mouse
  • Rat
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • Ctnnd2
  • Catnd2
  • Nprap
Purification MethodProtein A purified.
UniProt Number
UniProt SummaryFUNCTION: SwissProt: O35927 # Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:17993462) (PubMed:25807484). Involved in the regulation of canonical Wnt signaling (By similarity). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (PubMed:20623542). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. Functions as a transcriptional activator when bound to ZBTB33 (PubMed:15282317).
SIZE: 1247 amino acids; 135000 Da
SUBUNIT: Binds to E-cadherin at a juxtamembrane site within the cytoplasmic domain. Binds to PSEN1. Interacts with PDZD2 (By similarity). Interacts (via the extreme C-terminus) with FRMPD2 (via the PDZ 2 domain) (By similarity). Interacts with ZBTB33. Interacts with ARHGEF28 (PubMed:17993462). Interacts with CDK5 (By similarity). Interacts with CTNNB1 (By similarity). Interacts with GSK3A and GSK3B (PubMed:20623542) (PubMed:19706605). Interacts with DNM2 (By similarity).
SUBCELLULAR LOCATION: Nucleus. Cell junction, adherens junction. Cell projection, dendrite. Perikaryon (By similarity).
TISSUE SPECIFICITY: Expressed in neurons and glial cells. Isoform 2 was found to be the most predominant isoform in various brain regions. Expressed at neuromuscular junctions.
PTM: O-glycosylated. Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: SwissProt: O35927 ## Belongs to the beta-catenin family. & Contains 9 ARM repeats.
Molecular Weight133kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by immunoblot on rat brain microsomes.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions2 years at -20°C
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
07-259 04053252587368

Documentation

Anti-δ-Catenin Antibody Certificates of Analysis

TitleLot Number
Anti-delta;-Catenin - 22056 22056

References

Reference overviewPub Med ID
Caspase-3 cleavage links delta-catenin to the novel nuclear protein ZIFCAT.
Gu, D; Tonthat, NK; Lee, M; Ji, H; Bhat, KP; Hollingsworth, F; Aldape, KD; Schumacher, MA; Zwaka, TP; McCrea, PD
The Journal of biological chemistry  286  23178-88  2011

Show Abstract
21561870 21561870
Delta-catenin-induced dendritic morphogenesis. An essential role of p190RhoGEF interaction through Akt1-mediated phosphorylation.
Kim, H; Han, JR; Park, J; Oh, M; James, SE; Chang, S; Lu, Q; Lee, KY; Ki, H; Song, WJ; Kim, K
The Journal of biological chemistry  283  977-87  2008

Show Abstract
17993462 17993462
Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells.
Thelemann, A; Petti, F; Griffin, G; Iwata, K; Hunt, T; Settinari, T; Fenyo, D; Gibson, N; Haley, JD
Molecular & cellular proteomics : MCP  4  356-76  2005

Show Abstract
15657067 15657067