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MAB317 Anti-Calcitonin Gene Related Peptide Antibody, α hCGRP a.a. 28-37, clone CD8

MAB317
50 µg  
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Overview

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
Gp, HELISA, IHCMPurifiedMonoclonal Antibody
Description
Catalogue NumberMAB317
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Calcitonin Gene Related Peptide Antibody, α hCGRP a.a. 28-37, clone CD8
Product Information
FormatPurified
Quality LevelMQ100
Applications
ApplicationAnti-Calcitonin Gene Related Peptide Antibody, α hCGRP a.a. 28-37, clone CD8 is an antibody against Calcitonin Gene Related Peptide for use in ELISA, IH.
Key Applications
  • ELISA
  • Immunohistochemistry
Application NotesImmunohistochemistry at 1:200-1:400. Antibody not reactive on formalin fixed tissues. 4% PFA frozen tissues preferred. Immersion (2 hours) or perfused (pH7.4); Blocking in PBS with 3% BSA or NGS containing 0.1% triton X-100 is advised. Primary antibody should be diluted only in PBS with no detergent or blocking compounds.

ELISA: against BSA-conjugated alpha CGRP peptide.



Optimal working dilutions to be determined by end user.
Biological Information
ImmunogenA terminal fragment of hCGRP coupled to BSA with glutaraldehyde.
Epitopealpha hCGRP a.a. 28-37
CloneCD8
HostMouse
SpecificityHighly specific for CGRP and does not cross-react with other amino acids.
IsotypeIgG1
Species Reactivity
  • Guinea Pig
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryCalcitonin is a peptide hormone synthesized by the parafollicular cells of the thyroid. It causes reduction in serum calcium, an effect opposite to that of parathyroid hormone (PTH; MIM 168450).[supplied by OMIM]
Gene Symbol
  • CALCA
  • CGRP-I
  • katacalcin
  • KC
  • CALC1
  • CGRP
  • MGC126648
  • calcitonin
  • CT
  • CGRP1
Non-Reactive Species
  • Rat
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P01258 # Katacalcin is a potent plasma calcium-lowering peptide.| P06881 # CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP.
SIZE: 141 amino acids; 15467 Da
SUBCELLULAR LOCATION: Secreted.
DOMAIN: SwissProt: P01258
SIMILARITY: SwissProt: P01258 ## Belongs to the calcitonin family.| P06881 ## Belongs to the calcitonin family.
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain refrigerated at 2-8°C for up to 12 months.
Packaging Information
Material Size50 µg
Global Trade Item Number
Catalogue Number GTIN
MAB317 08436037124266