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176905 Anthrax Protective Antigen, Bacillus anthracis, Recombinant, B. anthracis - Calbiochem

Anthrax Protective Antigen, Bacillus anthracis, Recombinant, is the protective antigen that mediates the entry of anthrax lethal factor and edema factor into the target cell.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
176905
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Overview

Products

Catalogue NumberPackaging Qty/Pack
176905-100UG Plastic ampoule 100 μg
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Description
OverviewRecombinant, Bacillus anthracis anthrax protective antigen expressed in a specialized strain of B. anthracis. One of the three protein components of Anthrax toxin, protective antigen (PA) is the central moiety that mediates the entry of lethal factor and edema factor into the target cell. PA binds to the cell surface via a type I membrane protein with a von Willebrand factor A domain called anthrax toxin receptor. After proteolytic activation to a 63 kDa fragment, PA self-associates to form a heptameric cation-selective, voltage-gated membrane channel.
Catalogue Number176905
Brand Family Calbiochem®
References
ReferencesMogridge, J., et al. 2002. Biochemistry 41, 1079.
Nassi, S., et al. 2002. Biochemistry 41, 1445.
Ahuja, N., et al. 2001. Biochem. Biophys. Res. Commun. 286, 6.
Bradley, K.A., et al. 2001. Nature 414, 225.
Brossier, F., and Mock, M. 2001. Toxicon 39, 1747.
Product Information
ATP CompetitiveN
FormLyophilized
FormulationLyophilized from 50 mM NaCl, 5 mM HEPES, pH 7.5.
ReversibleN
Quality LevelMQ100
Applications
ApplicationAnthrax Protective Antigen, Bacillus anthracis, Recombinant, is the protective antigen that mediates the entry of anthrax lethal factor and edema factor into the target cell.
Biological Information
Primary TargetType I membrane protein with a von Willebrand factor A domain called anthrax toxin receptor
PuritySingle major band by SDS-PAGE. Several smaller minor components are apparent that may represent cleavage fragments of the PA.
Physicochemical Information
Cell permeableN
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions. Stock solutions are stable for up to 6 months at -20°C.
End use certificateY
Global Trade Item Number
Catalogue Number GTIN
176905-100UG 04055977223040