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182690 AhR Agonist V, VAF347 - CAS 574759-62-9 - Calbiochem

The AhR Agonist V, VAF347 controls the biological activity of AhR. This small molecule/inhibitor is primarily used for Biochemicals applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (4-(3-Chloro-phenyl)-pyrimidin-2-yl)-(4-trifluoromethyl-phenyl)-amine

182690
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Overview

Products

Catalogue NumberPackaging Qty/Pack
182690-10MG Glass bottle 10 mg
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Description
OverviewA cell-permeable pyrimidinylphenylamine compound that directly and reversibly targets aryl hydrocarbon receptor (AhR) with high-affinity, and induces AhR signaling. Reported to act as an immunomodulator with anti-inflammatory properties. Potently suppresses IgE secretion in B-cells with an IC50 of ~2 nM, and inhibits dendritic cells-mediated T-cell proliferation and cytokine production. Further, decreases lung eosinophilia in B-cell-deficient mice, and allergic inflammation. Downregulates PU.1 transcription factor, and impairs human monocytes and Langerhans dendritic cells differentiation.
Catalogue Number182690
Brand Family Calbiochem®
Synonyms(4-(3-Chloro-phenyl)-pyrimidin-2-yl)-(4-trifluoromethyl-phenyl)-amine
References
ReferencesPlatzer, B., et al. 2009. J. Immunol. 183, 66.
Hauben, E., et al. 2008. Blood 118, 1214.
Lawrence, B.P., et al. 2008. Blood 112, 1158.
Ettmayer, P., et al. 2006. Am. J. Respir. Crit. Care Med. 173, 599.
Product Information
CAS number574759-62-9
FormWhite solid
Hill FormulaC₁₇H₁₁ClF₃N₃
Chemical formulaC₁₇H₁₁ClF₃N₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥99% by HPLC
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
182690-10MG 04055977204445