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121765 AG 825 - CAS 149092-50-2 - Calbiochem

A potent, cell-premeable, reversible, substrate competitive, and selective inhibitor of HER2 (neu/ErbB2; IC₅₀ = 0.35 µM) relative to HER1 (IC₅₀= 19 µM) autophosphorylation.

AG 825 - CAS 149092-50-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-Hydroxy-3-methoxy-5-(benzothiazolylthiomethyl)benzylidenecyanoacetamide

Primary Target: HER2
121765
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
149092-50-2C₁₉H₁₅N₃O₃S₂

Products

Catalogue NumberPackaging Qty/Pack
121765-2MG Plastic ampoule 2 mg
Description
OverviewA potent, cell-premeable, reversible, substrate competitive, and selective inhibitor of HER2 (neu/ErbB2; IC50 = 0.35 µM) relative to HER1 (IC50 = 19 µM) autophosphorylation. The inhibition is competitive with respect to ATP binding. Enhances chemosensitivity in non-small cell lung cancer (NSCLC) cell lines expressing high levels of p185neu.
Catalogue Number121765
Brand Family Calbiochem®
Synonyms4-Hydroxy-3-methoxy-5-(benzothiazolylthiomethyl)benzylidenecyanoacetamide
References
ReferencesAshton, J.M., et al. 2012. Cell Stem Cell 11, 359.
Tsai, C.M., et al. 1996. Cancer Res. 56, 1068.
Levitzki, A., and Gazit, A. 1995. Science 267, 1782.
Osherov, N., et al. 1993. J. Biol. Chem. 268, 11134.
Product Information
CAS number149092-50-2
ATP CompetitiveN
FormYellow solid
Hill FormulaC₁₉H₁₅N₃O₃S₂
Chemical formulaC₁₉H₁₅N₃O₃S₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetHER2
Primary Target IC<sub>50</sub>0.35 µM against HER2
Purity≥94% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2-3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
121765-2MG 07790788047917

Documentation

AG 825 - CAS 149092-50-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

AG 825 - CAS 149092-50-2 - Calbiochem Certificates of Analysis

TitleLot Number
121765

References

Reference overview
Ashton, J.M., et al. 2012. Cell Stem Cell 11, 359.
Tsai, C.M., et al. 1996. Cancer Res. 56, 1068.
Levitzki, A., and Gazit, A. 1995. Science 267, 1782.
Osherov, N., et al. 1993. J. Biol. Chem. 268, 11134.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision24-March-2015 JSW
Synonyms4-Hydroxy-3-methoxy-5-(benzothiazolylthiomethyl)benzylidenecyanoacetamide
DescriptionA potent, cell-premeable, reversible, substrate competitive, and selective inhibitor of HER-2 (neu/erbB-2, IC50 = 0.35 µM) relative to HER-1 (IC50 = 19 µM) autophosphorylation. The inhibition is competitive with respect to ATP binding. Enhances the chemosensitivity in non-small cell lung cancer (NSCLC) cell lines expressing high levels of p185neu.
FormYellow solid
CAS number149092-50-2
Chemical formulaC₁₉H₁₅N₃O₃S₂
Structure formulaStructure formula
Purity≥94% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2-3 months at -20°C.
Toxicity Standard Handling
ReferencesAshton, J.M., et al. 2012. Cell Stem Cell 11, 359.
Tsai, C.M., et al. 1996. Cancer Res. 56, 1068.
Levitzki, A., and Gazit, A. 1995. Science 267, 1782.
Osherov, N., et al. 1993. J. Biol. Chem. 268, 11134.