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658395 AG 18 - CAS 118409-57-7 - Calbiochem

A broad-spectrum protein tyrosine kinase inhibitor.

AG 18 - CAS 118409-57-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: α-Cyano-(3,4-dihydroxy)cinnamonitrile, Tyrphostin A23, RG-50810

Primary Target: epidermal growth factor receptor autophosphorylation
658395
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
118409-57-7C₁₀H₆N₂O₂

Products

Catalogue NumberPackaging Qty/Pack
658395-5MG Plastic ampoule 5 mg
Description
OverviewA broad-spectrum protein tyrosine kinase inhibitor. Inhibits epidermal growth factor receptor autophosphorylation (IC50 = 40 µM) and the GTPase activity of transducin (IC50 = 10 µM). Inhibits aldosterone secretion in response to Angiotensin II (Cat. No. 05-23-0101). Suppresses the activation of MAP kinases by cholecystokinin in pancreatic acini.
Catalogue Number658395
Brand Family Calbiochem®
Synonymsα-Cyano-(3,4-dihydroxy)cinnamonitrile, Tyrphostin A23, RG-50810
References
ReferencesJaleel, M., et al. 2004. Biochemistry 43, 8247.
Kapas, S., et al. 1995. Biochem. J. 305, 433.
Seger, R., et al. 1995. J. Biol. Chem. 270, 28325.
Williams, J.A. 1994. Am. J. Physiol. 267, G401.
Geissler, J.F., et al. 1990. J. Biol. Chem. 265, 22255.
Levitzki, A. 1990. Biochem. Pharmacol. 40, 913.
Gazit, A., et al. 1989. J. Med. Chem. 32, 2344.
Lyall, R.M., et al. 1989. J. Biol. Chem. 264, 14503.
Product Information
CAS number118409-57-7
ATP CompetitiveN
FormYellow solid
Hill FormulaC₁₀H₆N₂O₂
Chemical formulaC₁₀H₆N₂O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetepidermal growth factor receptor autophosphorylation
Primary Target IC<sub>50</sub>40 µM against epidermal growth factor receptor autophosphorylation; 10 µM against GTPase activity of transducin
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
658395-5MG 04055977261547

Documentation

AG 18 - CAS 118409-57-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

AG 18 - CAS 118409-57-7 - Calbiochem Certificates of Analysis

TitleLot Number
658395

References

Reference overview
Jaleel, M., et al. 2004. Biochemistry 43, 8247.
Kapas, S., et al. 1995. Biochem. J. 305, 433.
Seger, R., et al. 1995. J. Biol. Chem. 270, 28325.
Williams, J.A. 1994. Am. J. Physiol. 267, G401.
Geissler, J.F., et al. 1990. J. Biol. Chem. 265, 22255.
Levitzki, A. 1990. Biochem. Pharmacol. 40, 913.
Gazit, A., et al. 1989. J. Med. Chem. 32, 2344.
Lyall, R.M., et al. 1989. J. Biol. Chem. 264, 14503.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-May-2011 RFH
Synonymsα-Cyano-(3,4-dihydroxy)cinnamonitrile, Tyrphostin A23, RG-50810
DescriptionA cell-permeable, reversible, substrate competitive protein tyrosine kinase inhibitor. Inhibits epidermal growth factor receptor autophosphorylation (IC50 = 40 µM) and the GTPase activity of transducin (IC50 = 10 µM). Inhibits aldosterone secretion in response to angiotensin II. Suppresses the activation of MAP kinases by cholecystokinin in pancreatic acini. Also reported to inhibit guanylyl cyclase.
FormYellow solid
CAS number118409-57-7
Chemical formulaC₁₀H₆N₂O₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityAcetic acid, DMSO (100 mg/ml), or ethanol (50 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesJaleel, M., et al. 2004. Biochemistry 43, 8247.
Kapas, S., et al. 1995. Biochem. J. 305, 433.
Seger, R., et al. 1995. J. Biol. Chem. 270, 28325.
Williams, J.A. 1994. Am. J. Physiol. 267, G401.
Geissler, J.F., et al. 1990. J. Biol. Chem. 265, 22255.
Levitzki, A. 1990. Biochem. Pharmacol. 40, 913.
Gazit, A., et al. 1989. J. Med. Chem. 32, 2344.
Lyall, R.M., et al. 1989. J. Biol. Chem. 264, 14503.