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100110 AAPH - CAS 2997-92-4 - Calbiochem

AAPH, CAS 2997-92-4, is a heat-sensitive, water-soluble, free radical initiator. Induces oxidative stress to cause lipid peroxidation, protein modification & DNA strand breakage.

AAPH - CAS 2997-92-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: ABAP, 2,2ʹ-Azobis-(2-amidinopropane), 2HCl, 2,2ʹ-Azobis-(2-methylpropionamidine), 2HCl

100110
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
2997-92-4C₈H₁₈N₆ · 2HCl
Description
Overview

This product has been discontinued.



A heat-sensitive, water-soluble, free radical initiator that induces oxidative stress by causing cellular damage associated with lipid peroxidation, protein modification, hemoglobin oxidation, and DNA strand breakage. Reported to induce apoptosis in HL-60 cells via activation of caspase-3.
Catalogue Number100110
Brand Family Calbiochem®
SynonymsABAP, 2,2ʹ-Azobis-(2-amidinopropane), 2HCl, 2,2ʹ-Azobis-(2-methylpropionamidine), 2HCl
References
ReferencesIshika, R., et al. 2001. J. Biochem. (Tokyo) 129, 35.
Raneva, V., et al. 2001. Lipids 36, 1111.
Thomas, M.J., et al. 2001. Biochemistry 40, 1719.
Kwon, H.Y., et al. 2000. Biochem. Biophys. Acta 1543, 69.
Bassett, C.N., et al. 1999. Lipids 34, 1273.
Viner, R.I., et al. 1997. Biochemistry 36, 7706.
Kanno, T., et al. 1994. Free Radic. Res. 21, 223.
Product Information
CAS number2997-92-4
ATP CompetitiveN
FormWhite solid
Hill FormulaC₈H₁₈N₆ · 2HCl
Chemical formulaC₈H₁₈N₆ · 2HCl
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationAAPH, CAS 2997-92-4, is a heat-sensitive, water-soluble, free radical initiator. Induces oxidative stress to cause lipid peroxidation, protein modification & DNA strand breakage.
Biological Information
Primary TargetFree radical initiator that induces oxidative stress
Purity≥96% by titration
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSUE4575500
Safety Information
R PhraseR: 20/21/22-36/37/38-42/43

Harmful by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
May cause sensitization by inhalation and skin contact.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 24 h at 4°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
100110 0

Documentation

AAPH - CAS 2997-92-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

AAPH - CAS 2997-92-4 - Calbiochem Certificates of Analysis

TitleLot Number
100110

References

Reference overview
Ishika, R., et al. 2001. J. Biochem. (Tokyo) 129, 35.
Raneva, V., et al. 2001. Lipids 36, 1111.
Thomas, M.J., et al. 2001. Biochemistry 40, 1719.
Kwon, H.Y., et al. 2000. Biochem. Biophys. Acta 1543, 69.
Bassett, C.N., et al. 1999. Lipids 34, 1273.
Viner, R.I., et al. 1997. Biochemistry 36, 7706.
Kanno, T., et al. 1994. Free Radic. Res. 21, 223.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-June-2008 JSW
SynonymsABAP, 2,2ʹ-Azobis-(2-amidinopropane), 2HCl, 2,2ʹ-Azobis-(2-methylpropionamidine), 2HCl
DescriptionA heat-sensitive, water-soluble, free radical initiator that induces oxidative stress by causing cellular damage associated with lipid peroxidation, protein modification, hemoglobin oxidation, and DNA strand breakage. Reported to induce apoptosis in HL-60 cells via activation of caspase-3 by lysosomal cysteine proteases. Particularly useful in inducing cell death at hyperthermic temperatures.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number2997-92-4
RTECSUE4575500
Chemical formulaC₈H₁₈N₆ · 2HCl
Structure formulaStructure formula
Purity≥96% by titration
SolubilityH₂O (20 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 24 h at 4°C.
Toxicity Harmful
ReferencesIshika, R., et al. 2001. J. Biochem. (Tokyo) 129, 35.
Raneva, V., et al. 2001. Lipids 36, 1111.
Thomas, M.J., et al. 2001. Biochemistry 40, 1719.
Kwon, H.Y., et al. 2000. Biochem. Biophys. Acta 1543, 69.
Bassett, C.N., et al. 1999. Lipids 34, 1273.
Viner, R.I., et al. 1997. Biochemistry 36, 7706.
Kanno, T., et al. 1994. Free Radic. Res. 21, 223.