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100122 Sigma-AldrichA3, Hydrochloride

A3, Hydrochloride MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

CoA
References
Data Sheet

Synonyms: N-(2-Aminoethyl)-5-chloronaphthalene-1-sulfonamide, HCl

Primary Target: CK1

Recommended Products

Overview

Replacement Information

Key Spec Table

CAS #	Empirical Formula
78957-85-4	C₁₂H₁₃ClN₂O₂S · HCl

Description
Overview	This product has been discontinued. A cell-permeable, reversible, and shorter alkyl chain derivative of W-7 that inhibits casein kinase I (K_i = 80 µM), casein kinase II (K_i = 5.1 µM), myosin light chain kinase (K_i = 7.4 µM), protein kinase A (K_i = 4.3 µM), protein kinase C (K_i = 47 µM), and protein kinase G (K_i = 3.8 µM).
Catalogue Number	100122
Brand Family	Calbiochem®
Synonyms	N-(2-Aminoethyl)-5-chloronaphthalene-1-sulfonamide, HCl

References
References	Inagaki, M., et al. 1986. Mol. Pharmacol. 29, 577. Turner, E.J.H., et al. 2003. Br. J. Haematol. 120, 894.

Product Information
CAS number	78957-85-4
Form	Off-white solid
Hill Formula	C₁₂H₁₃ClN₂O₂S · HCl
Chemical formula	C₁₂H₁₃ClN₂O₂S · HCl
Hygroscopic	Hygroscopic
Structure formula Image

Applications

Biological Information
Primary Target	CK1
Primary Target K<sub>i</sub>	80 µM
Secondary target	CK2 (K_i = 5.1 µM), MLCK (K_i = 7.4 µM), PKA (K_i = 4.3 µM), PKC (K_i = 47 µM), PKG (K_i = 3.8 µM)
Purity	≥98% by TLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
Catalogue Number	GTIN
100122	0

Documentation

A3, Hydrochloride Certificates of Analysis

Title	Lot Number
100122	Enter Lot Number

References

Reference overview
Inagaki, M., et al. 1986. Mol. Pharmacol. 29, 577. Turner, E.J.H., et al. 2003. Br. J. Haematol. 120, 894.

Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	04-April-2011 RFH
Synonyms	N-(2-Aminoethyl)-5-chloronaphthalene-1-sulfonamide, HCl
Description	A cell-permeable, reversible, and shorter alkyl chain derivative of W-7 that inhibits casein kinase I (K_i= 80 µM), casein kinase II (K_i= 5.1 µM), myosin light chain kinase (K_i= 7.4 µM), protein kinase A (K_i= 4.3 µM), protein kinase C (K_i= 47 µM) and protein kinase G (K_i= 3.8 µM).
Form	Off-white solid
CAS number	78957-85-4
Chemical formula	C₁₂H₁₃ClN₂O₂S · HCl
Structure formula
Purity	≥98% by TLC
Solubility	DMSO (25 mg/ml) or 50% Ethanol (20 mg/ml)
Storage	-20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Inagaki, M., et al. 1986. Mol. Pharmacol. 29, 577. Turner, E.J.H., et al. 2003. Br. J. Haematol. 120, 894.

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