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402087 7BIO - CAS 916440-85-2 - Calbiochem

A cell-permeable 6-BIO structural isomer that acts as an ATP-competitive inhibitor of Flt3 and a caspase-independent, non-apoptotic cell death inducer.

7BIO - CAS 916440-85-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (2ʹZ,3ʹE)-7-Bromoindirubin-3ʹ-oxime, Indirubin-3ʹ-monoxime, 7-Bromo, 7-Bromoindirubin-oxime

402087
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
916440-85-2C₁₆H₁₀BrN₃O₂
Description
OverviewA cell-permeable 6-BIO (Cat. Nos. 361550 and 361552) structural isomer that acts as an ATP-competitive inhibitor of Flt3 (IC50 = 340 nM) and a caspase-independent, non-apoptotic cell death inducer (IC50 of cell survival ranges from 6.0 µM to 22.0 µM). Inhibition study against 75 other kinases reveals 10- to 80-fold selectivities over a group of 14 kinases, including TSF1, Aurora-A, and Aurora-B (IC50 = 3.3, 4.7, and 6.6 µM, respectively), up to 280-fold selectivities over a second group of 15 kinases, and little activity against the remaining 46 kinases of the panel (IC50 >100 µM).
Catalogue Number402087
Brand Family Calbiochem®
Synonyms(2ʹZ,3ʹE)-7-Bromoindirubin-3ʹ-oxime, Indirubin-3ʹ-monoxime, 7-Bromo, 7-Bromoindirubin-oxime
References
ReferencesZahler, S., et al. 2007. Chem. Biol. 14, 1207.
Myrianthopoulos, V., et al. 2007. J. Med. Chem. 50, 4027.
Ferandin, Y., et al. 2006. J. Med. Chem. 49, 4638.
Ribas, J., et al. 2006. Oncogene 25, 6304.
Product Information
CAS number916440-85-2
FormDeep black-red solid
Hill FormulaC₁₆H₁₀BrN₃O₂
Chemical formulaC₁₆H₁₀BrN₃O₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Regulatory Review
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
402087 0

Documentation

7BIO - CAS 916440-85-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

7BIO - CAS 916440-85-2 - Calbiochem Certificates of Analysis

TitleLot Number
402087

References

Reference overview
Zahler, S., et al. 2007. Chem. Biol. 14, 1207.
Myrianthopoulos, V., et al. 2007. J. Med. Chem. 50, 4027.
Ferandin, Y., et al. 2006. J. Med. Chem. 49, 4638.
Ribas, J., et al. 2006. Oncogene 25, 6304.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-May-2011 RFH
Synonyms(2ʹZ,3ʹE)-7-Bromoindirubin-3ʹ-oxime, Indirubin-3ʹ-monoxime, 7-Bromo, 7-Bromoindirubin-oxime
DescriptionA cell-permeable 6-BIO (Cat. Nos. 361550 and 361552) structural isomer that acts as an ATP-competitive inhibitor of Flt3 (IC50 = 340 nM) and a caspase-independent, non-apoptotic cell death inducer (IC50 of cell survival ranges from 6.0 µM to 22.0 µM). Inhibition study against 75 other kinases reveals 10- to 80-fold selectivities over a group of 14 kinases, including TSF1, Aurora-A, and Aurora-B (IC50 = 3.3, 4.7, and 6.6 µM, respectively), up to 280-fold selectivities over a second group of 15 kinases, and little activity against the remaining 46 kinases of the panel (IC50 >100 µM).
FormDeep black-red solid
Intert gas (Yes/No) Packaged under inert gas
CAS number916440-85-2
Chemical formulaC₁₆H₁₀BrN₃O₂
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Regulatory Review
ReferencesZahler, S., et al. 2007. Chem. Biol. 14, 1207.
Myrianthopoulos, V., et al. 2007. J. Med. Chem. 50, 4027.
Ferandin, Y., et al. 2006. J. Med. Chem. 49, 4638.
Ribas, J., et al. 2006. Oncogene 25, 6304.