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100050 1400W - CAS 214358-33-5 - Calbiochem

A selective, cell-permeable, irreversible, slow, tight-binding inhibitor of inducible nitric oxide synthase (iNOS; Kd = 7 nM).

1400W - CAS 214358-33-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(3-Aminomethyl)benzylacetamidine, 2HCl

Primary Target: iNOS
100050
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
214358-33-5C₁₀H₁₅N₃ · 2HCl

Products

Catalogue NumberPackaging Qty/Pack
100050-5MG Plastic ampoule 5 mg
Description
OverviewA selective, cell-permeable, irreversible, slow, tight-binding inhibitor of inducible nitric oxide synthase (iNOS; Kd = 7 nM). Suitable for use in both in vitro and in vivo systems. Has a protective effect against cerebral ischemia by reducing ischemic lesion volumes. Exhibits greater than 5000- and 200-fold potency against human iNOS relative to eNOS and nNOS, respectively, and greater than 1000-fold potency against rat iNOS relative to eNOS.
Catalogue Number100050
Brand Family Calbiochem®
SynonymsN-(3-Aminomethyl)benzylacetamidine, 2HCl
References
ReferencesParmentier, S., et al. 1999. Br. J. Pharmacol. 127, 546.
Cardenas, A., et al. 1998. Eur. J. Pharmacol. 354, 161.
Parrino, P.E., et al. 1998. Ann. Thorac. Surg. 66, 733.
Garvey, E.P., et al. 1997. J. Biol. Chem. 272, 4959.
Laszlo, F., and Whittle, B.J. 1997. Eur. J. Pharmacol. 334, 99.
Thomsen, L.L., et al. 1997. Cancer Res. 57, 3300.
Product Information
CAS number214358-33-5
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₀H₁₅N₃ · 2HCl
Chemical formulaC₁₀H₁₅N₃ · 2HCl
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetiNOS
Primary Target IC<sub>50</sub>Kd = 7 nM against inducible nitric oxide synthase (iNOS)
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
100050-5MG 04055977226867

Documentation

1400W - CAS 214358-33-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

1400W - CAS 214358-33-5 - Calbiochem Certificates of Analysis

TitleLot Number
100050

References

Reference overview
Parmentier, S., et al. 1999. Br. J. Pharmacol. 127, 546.
Cardenas, A., et al. 1998. Eur. J. Pharmacol. 354, 161.
Parrino, P.E., et al. 1998. Ann. Thorac. Surg. 66, 733.
Garvey, E.P., et al. 1997. J. Biol. Chem. 272, 4959.
Laszlo, F., and Whittle, B.J. 1997. Eur. J. Pharmacol. 334, 99.
Thomsen, L.L., et al. 1997. Cancer Res. 57, 3300.

Brochure

Title
Pathways and Biomarkers of Oxidative Stress

Citations

Title
  • Peyssonnaux, C., et al. 2005. The Journal of Clinical Investigation 115, 1860.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision04-April-2011 RFH
    SynonymsN-(3-Aminomethyl)benzylacetamidine, 2HCl
    DescriptionA selective, irreversible, slow, tight binding inhibitor of inducible nitric oxide synthase (iNOS, Kd = 7 nM) both in vitro and in vivo. Has a protective effect against cerebral ischemia by reducing ischemic lesion volumes. Exhibits greater than 5000- and 200-fold potency against human iNOS relative to eNOS and nNOS, respectively, and greater than 1000-fold potency against rat iNOS relative to eNOS.
    FormWhite solid
    Intert gas (Yes/No) Packaged under inert gas
    CAS number214358-33-5
    Chemical formulaC₁₀H₁₅N₃ · 2HCl
    Structure formulaStructure formula
    Purity≥95% by HPLC
    SolubilityMethanol (5 mg/ml) or H₂O (1 mg/ml)
    Storage -20°C
    Hygroscopic
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable up to 3 months at -20°C.
    Toxicity Standard Handling
    ReferencesParmentier, S., et al. 1999. Br. J. Pharmacol. 127, 546.
    Cardenas, A., et al. 1998. Eur. J. Pharmacol. 354, 161.
    Parrino, P.E., et al. 1998. Ann. Thorac. Surg. 66, 733.
    Garvey, E.P., et al. 1997. J. Biol. Chem. 272, 4959.
    Laszlo, F., and Whittle, B.J. 1997. Eur. J. Pharmacol. 334, 99.
    Thomsen, L.L., et al. 1997. Cancer Res. 57, 3300.
    Citation
  • Peyssonnaux, C., et al. 2005. The Journal of Clinical Investigation 115, 1860.
    		•