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565772 γ-Secretase Inhibitor XI - CAS 62252-26-0 - Calbiochem

The γ-Secretase Inhibitor XI, also referenced under CAS 62252-26-0, controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 7-Amino-4-chloro-3-methoxyisocoumarin, JLK6

Primary Target: γ-secretase and blocks the production of both Aβ₄₀ and Aβ₄₂ in HEK293 cells expressing wild-type and Swedish-mutant β-amyloid precursor protein (APP)
565772
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
62252-26-0C₁₀H₈ClNO₃
Description
Overview

This product has been discontinued.



A cell-permeable, active site directed, irreversible serine protease inhibitor that belongs to the class of isocoumarin analogs. Acts as a potent and selective inhibitor of γ-secretase and blocks the production of both amyloid-β40 (Aβ40) and Aβ42 (IC50 < 100 µM) in HEK293 cells expressing wild-type and Swedish-mutant β-amyloid precursor protein (APP).
Note: t1/2 = 200 min in 100 µM HEPES, 500 µM NaCl, and 10% DMSO, pH 7.5.
Catalogue Number565772
Brand Family Calbiochem®
Synonyms7-Amino-4-chloro-3-methoxyisocoumarin, JLK6
References
ReferencesEsler, W.P., et al. 2002. Nat. Cell Biol. 4, E110.
Petit, A., et al. 2002. Nat. Cell Biol. 4, E111.
Petit, A., et al. 2001. Nat. Cell Biol. 3, 507.
Kerrigan, J.E., et al. 1995. J. Med. Chem. 38, 544.
Harper, J.W. and Powers, J.C. 1985. Biochemistry 24, 7200.
Product Information
CAS number62252-26-0
ATP CompetitiveN
FormYellow solid
Hill FormulaC₁₀H₈ClNO₃
Chemical formulaC₁₀H₈ClNO₃
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary Targetγ-secretase and blocks the production of both Aβ₄₀ and Aβ₄₂ in HEK293 cells expressing wild-type and Swedish-mutant β-amyloid precursor protein (APP)
Primary Target IC<sub>50</sub>< 100 µM against γ-secretase and blocks the production of both amyloid-β40 (Aβ40) and Aβ42 in HEK293 cells expressing wild-type and Swedish-mutant β-amyloid precursor protein (APP)
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C. This product is not stable in aqueous solution, hence, dilute in aqueous solution right prior to use (t½ at 25°C = 3.3 h in 100 mM HEPES, 500 mM NaCl, pH 7.5, with 10% DMSO).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
565772 0

Documentation

γ-Secretase Inhibitor XI - CAS 62252-26-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

γ-Secretase Inhibitor XI - CAS 62252-26-0 - Calbiochem Certificates of Analysis

TitleLot Number
565772

References

Reference overview
Esler, W.P., et al. 2002. Nat. Cell Biol. 4, E110.
Petit, A., et al. 2002. Nat. Cell Biol. 4, E111.
Petit, A., et al. 2001. Nat. Cell Biol. 3, 507.
Kerrigan, J.E., et al. 1995. J. Med. Chem. 38, 544.
Harper, J.W. and Powers, J.C. 1985. Biochemistry 24, 7200.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-April-2011 RFH
Synonyms7-Amino-4-chloro-3-methoxyisocoumarin, JLK6
DescriptionA non-peptidic, cell-permeable, active site-directed, irreversible serine protease inhibitor that belongs to the class of isocoumarin analogs. Acts as a potent and selective inhibitor of γ-secretase and blocks the production of both amyloid-β 40 (Aβ40) and 42 (Aβ42) in HEK293 cells (70-80% inhibition at 100 µM concentration) expressing wild-type and Swedish-mutant β-amyloid precursor protein (βAPP). Does not exhibit any significant effect on either the processing or mΔEnotch-1 or the endoproteolysis of presenilins.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number62252-26-0
Chemical formulaC₁₀H₈ClNO₃
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C. This product is not stable in aqueous solution, hence, dilute in aqueous solution right prior to use (t½ at 25°C = 3.3 h in 100 mM HEPES, 500 mM NaCl, pH 7.5, with 10% DMSO).
Toxicity Standard Handling
ReferencesEsler, W.P., et al. 2002. Nat. Cell Biol. 4, E110.
Petit, A., et al. 2002. Nat. Cell Biol. 4, E111.
Petit, A., et al. 2001. Nat. Cell Biol. 3, 507.
Kerrigan, J.E., et al. 1995. J. Med. Chem. 38, 544.
Harper, J.W. and Powers, J.C. 1985. Biochemistry 24, 7200.