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12-545 ZIPtide

ZIPtide primarily used in Kinase Assays.

ZIPtide MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
12-545
1 mg  
Purchase on Sigma-Aldrich

Przegląd

Replacement Information
Description
Catalogue Number12-545
Brand Family Upstate
Trade Name
  • Upstate
DescriptionZIPtide
References
Product Information
PresentationLyophilized powder
Quality LevelMQ100
Applications
ApplicationZIPtide primarily used in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Entrez Gene Number
Entrez Gene SummaryDeath-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis.
Gene Symbol
  • DAPK3
  • FLJ36473
  • ZIP-kinase
  • Dlk
  • ZIPK
  • ZIP
Protein TargetZIPK
Target Sub-FamilyCAMK
UniProt Number
UniProt SummaryFUNCTION: SwissProt: O43293 # Serine/threonine kinase which acts as a positive regulator of apoptosis. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis.
COFACTOR: Magnesium.
SIZE: 454 amino acids; 52536 Da
SUBUNIT: Homodimer or forms heterodimers with ATF4. Both interactions require an intact leucine zipper domain and oligomerization is required for full enzymatic activity. Also binds to DAXX and PAWR, possibly in a ternary complex which plays a role in caspase activation. Interacts with AATF and CDC5L.
SUBCELLULAR LOCATION: Nucleus. Cytoplasm (By similarity). Note=Relocates to the cytoplasm on binding PAWR where the complex appears to interact with actin filaments (By similarity). Associates to centromeres from prophase to anaphase.
SIMILARITY: SwissProt: O43293 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily. & Contains 1 protein kinase domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated as a substrate for ZIPK, active (14-608)
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions2 years at -20°C
Packaging Information
Material Size1 mg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Numer katalogowy GTIN
12-545 04053252741760

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Life Science Research > Proteins and Enzymes > Substrate & Control Proteins > Kinase & Phosphatase Substrates
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Kinase & Phosphatase Substrates