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676495 VEGF Inhibitor, V1 - Calbiochem

The VEGF Inhibitor, V1 controls the biological activity of VEGF. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

VEGF Inhibitor, V1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: ATWLPPR

Primary Target: Specifically competes against VEGF165 binding to recombinant NRP-1
676495
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Przegląd

Tabela kluczowych gatunków

Empirical Formula
C₄₀H₆₁N₁₁O₉

Products

Numer katalogowyOpakowanie Ilość/opak.
676495-1MG Ampulka plastikowa 1 mg
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Description
OverviewAn NRP-1-binding heptapeptide whose target was initially mistaken as VEGFR2/KDR/Flk-1 due to its binding activity to a CHO-KDR culture that was later shown to express primarily NRP-1 and little KDR. V1/A7R specifically competes against VEGF165 binding to recombinant NRP-1 in cell-free binding assays (IC50 = 60 µM), while exhibiting no activity against the interaction between NRP-1 and heparin or VEGF165 binding to KDR, VEGFR1/Flt-1, and heparin. V1/A7R is demonstrated to inhibit VEGF-dependent angiogenesis activity in HMVEC (IC50 = 0.3 µM) and HUVEC cultures in vitro, as well as in a rabbit corneal neovascularization model and in mice bearing MDA-MB-231-derived tumor in vivo.
Catalogue Number676495
Brand Family Calbiochem®
SynonymsATWLPPR
References
ReferencesStarzec, A., et al. 2006. Life Sci. 79, 2370.
Binetruy-Tournaire, R., et al. 2000. EMBO J. 19, 1525.
Product Information
ATP CompetitiveN
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₄₀H₆₁N₁₁O₉
Chemical formulaC₄₀H₆₁N₁₁O₉
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Biological Information
Primary TargetSpecifically competes against VEGF165 binding to recombinant NRP-1
Primary Target IC<sub>50</sub>60 µM for specifically competes against VEGF165 binding to recombinant NRP-1 in cell-free binding assays
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceH-Ala-Thr-Trp-Leu-Pro-Pro-Arg-OH
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Numer katalogowy GTIN
676495-1MG 04055977260472